BioCentury | Jul 23, 2015
Distillery Therapeutics

Therapeutics: HOX transcript antisense RNA (HOTAIR)

...studies suggest inhibiting the long noncoding RNA (lncRNA) HOTAIR could help treat glioblastoma multiforme (GBM). HOTAIR...
...with normal HOTAIR expression. In human glioblastoma cell lines, a BET bromodomain protein inhibitor decreased HOTAIR...
...with vehicle. Next steps include optimizing inhibitors of BET bromodomain proteins for CNS indications. TARGET/MARKER/PATHWAY: HOX transcript antisense RNA (HOTAIR)...
BioCentury | Feb 16, 2012
Distillery Therapeutics

Indication: Cancer

...Cancer Gastrointestinal cancer MicroRNA-196a (miR-196a); HOX transcript antisense RNA (HOTAIR) Patient sample and cell culture studies suggest miR-196a or HOTAIR...
...prognostic markers or therapeutic targets for gastrointestinal cancer. Patients with high levels of miR-196a or HOTAIR...
...shorter survival times than patients with low levels. In GIST cells, small interfering RNA against HOTAIR...
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