BioCentury | Aug 24, 2017
Preclinical News

Inhibiting PP2A reduces MECP2 in neuropsychiatric model

...an RNAi genetic screen and short hairpin RNA in cultured cells, the team showed that homeodomain interacting protein kinase 2 (HIPK2)...
...target MECP2. Chris Lieu Baylor College of Medicine Howard Hughes Medical Institute Stanford University Texas Children's Hospital University of California San Francisco Homeodomain interacting protein kinase 2 (HIPK2) Methyl...
BioCentury | Jun 16, 2016
Distillery Therapeutics

Therapeutics: Homeodomain interacting protein kinase 2 (HIPK2); TAR DNA binding protein 43 (TDP-43; TARDBP)

...Neurology INDICATION: Amyotrophic lateral sclerosis (ALS) In vitro and mouse studies suggest inhibiting HIPK2 could help...
...In HEK cells and rat spinal motor neurons expressing a human ALS-associated TDP-43 mutation, an HIPK2...
...HIPK2 expression. Next steps developing a HIPK2 inhibitor that crosses the blood-brain barrier (BBB). TARGET/MARKER/PATHWAY: Homeodomain interacting protein kinase 2 (HIPK2)...
BioCentury | May 12, 2016
Distillery Therapeutics

Therapeutics: Homeodomain interacting protein kinase 3 (HIPK3)

Cancer INDICATION: Cancer In vitro studies suggest inhibiting HIPK3 circular RNA (circRNA) could help treat colorectal, liver and other cancers. A screen for ribosomal-depleted RNA in samples of six normal human tissue types and seven...
BioCentury | Mar 22, 2012
Distillery Therapeutics

Indication: Renal disease

...and contact information Renal disease Renal damage Homeodomain interacting protein kinase 2 (HIPK2) Patient tissue and mouse studies suggest inhibiting HIPK2...
...kidney fibrosis. In kidneys from patients with diabetic neuropathy, HIV-associated nephropathy and focal segmental glomerulosclerosis, HIPK2...
...that in kidneys from healthy volunteers. In a mouse model of HIV-associated nephropathy, mice lacking Hipk2...
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