BioCentury | Jul 17, 2020
Deals

Bischofberger revisits Gilead castoff to pad Kronos’ pipeline of transcription modulators

New biomarker data for a clinical cancer therapy discontinued by Gilead prompted Kronos President and CEO Norbert Bischofberger to close a deal with his old company to bring the IP in-house to Kronos. The acquisition...
BioCentury | Jun 7, 2018
Clinical News

Exact HCC assay significantly better than SOC

...and 98 healthy controls. The HCC test measured a panel of six methylated DNA markers: homeobox A1 (HOXA1)...
...CLEC11A). Exact Sciences Corp. (NASDAQ:EXAS), Madison, Wis. Product: HCC blood test Business: Diagnostic Molecular target: Homeobox A1 (HOXA1)...
...Corp. C-type lectin domain family 11 member A (CLEC11A) Empty spiracles homeobox 1 (EMX1) Endothelin converting enzyme 1 (ECE1) Homeobox A1 (HOXA1) phosphofructokinase...
BioCentury | Jun 6, 2018
Product Development

Second (Ex)act

...of these markers were included in the HCC panel used in the Phase II trial: homeobox A1 (HOXA1)...
BioCentury | Jun 5, 2018
Clinical News

Exact HCC assay significantly better than SOC

...and 98 healthy controls. The HCC test measured a panel of six methylated DNA markers: homeobox A1 (HOXA1)...
...Corp. C-type lectin domain family 11 member A (CLEC11A) Empty spiracles homeobox 1 (EMX1) Endothelin converting enzyme 1 (ECE1) Homeobox A1 (HOXA1) phosphofructokinase...
BioCentury | Dec 10, 2015
Distillery Therapeutics

Therapeutics: Homeobox A9 (HOXA9); poly(ADP-ribose) polymerase (PARP); myeloid-lymphoid or mixed-lineage leukemia (MLL; HRX)

Cancer INDICATION: Acute myelogenous leukemia (AML) Cell culture and mouse studies suggest inhibiting HOXA9 and PARP could help treat MLL-rearranged AML. In primary AML cells from patients and mouse hematopoietic cells transformed with human leukemia-associated...
BioCentury | Jan 30, 2014
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Breast cancer Homeobox A1 (HOXA1) In vitro and mouse studies suggest depleting HOXA1...
...comparison of networks of gene expression changes in tumorigenic and wild-type mouse mammary glands identified Hoxa1...
...Hoxa1 decreased cell proliferation and tumor incidence compared with nonspecific siRNA. Next steps include profiling Hoxa1...
BioCentury | Jan 30, 2014
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML) MicroRNA-196b (miR-196b); miR-21 Patient sample, mouse and in vitro studies suggest inhibiting miR-196b and miR-21 could help...
BioCentury | Nov 21, 2011
Clinical News

ConfirmMDx for Lung Cancer diagnostic data

Data from sputum samples from 40 NSCLC patients and 52 symptomatic, cancer-free controls showed that using methylation specific PCR to screen for the methylated Ras association domain family 1A (RASSF1A) gene produced 60% sensitivity and...
BioCentury | Jul 28, 2011
Distillery Therapeutics

Indication: Cancer

...information Cancer Melanoma Acid phosphatase 5 tartrate resistant (ACP5); fascin homolog 1 actin-bundling protein (FSCN1); homeobox A1 (HOXA1)...
...containing 4 (VSIG4) A study in patient tissue, mice and cell culture suggests ACP5, FSCN1, HOXA1...
BioCentury | Dec 17, 2001
Company News

Amplistar other research news

Researchers published in the Proceedings of the National Academy of Sciences evidence that the homeobox gene HOXA7 product is selectively expressed on certain differentiated ovarian tumors and stimulates an immune response in patients. Analysis of...
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