BioCentury | May 13, 2020
Product Development

Arvinas unveils first efficacy signal for targeted protein degradation, points to opportunity in resistant cancers

...androgen receptor levels in tumor biopsies. Arvinas also disclosed adverse events in patients taking the HMG-CoA reductase...
BioCentury | Jun 19, 2019
Company News

June 18 Company Quick Takes: Sino-Akeso JV, plus Oxford Drug Design, Be The Match and more

...treat pediatric patients aged 8 years and older with heterozygous familial hypercholesterolemia, which gives the HMG-CoA reductase...
...Ltd. Kowa Co. Ltd. Merck & Co. Inc. Sino Biopharmaceutical Ltd. TrakCel Ltd. Fungal cytochrome P450 C-14 alpha demethylase (fungal CYP51) HMG-CoA reductase AK105 CNCT19 Juventas...
BioCentury | May 14, 2019
Distillery Therapeutics

Two generic antifungals and cerivastatin for biliary, pancreatic cancers

...339 drugs in organoids derived from one IHCC patient identified three non-cancer agents -- the HMG-CoA reductase...
...University Faculty of Pharmacy and Keio University School of Medicine, Tokyo, Japan email: saito-ys@pha.keio.ac.jp Sandi Wong Keio University HMG-CoA reductase Pancreatic...
BioCentury | Jan 3, 2019
Distillery Therapeutics

Cancer

...INDICATION: Liver cancer Cell culture and mouse studies suggest inhibiting the HMG-CoA reductase/SQLE/LSS pathway could help treat...
...p53-deficient mouse model of hepatocellular carcinoma (HCC), the HMG-CoA reductase inhibitor Lipitor atorvastatin or shRNAs targeting HMG-CoA reductase...
...III testing to treat atherosclerosis and Phase II testing to treat multiple sclerosis (MS). TARGET/MARKER/PATHWAY: HMG-CoA reductase...
BioCentury | Oct 31, 2018
Distillery Therapeutics

Cancer; infectious disease

...include testing simvastatin as a vaccine adjuvant in other cancer and infectious disease models. The HMG-CoA reductase...
BioCentury | Jul 6, 2018
Preclinical News

New uses for marketed drugs in tough-to-treat indications

...generics each separately increased myelin density, suggesting they prevented white matter damage. Simvastatin is an HMG-CoA reductase...
BioCentury | May 9, 2018
Distillery Therapeutics

Cardiovascular

...cerivastatin. In a rat model of PAH, intratracheal administration of liposomes loaded with cerivastatin, a HMG-CoA reductase...
...withdrew the HMG-CoA reductase inhibitor Baycol cerivastatin from the market for hypercholesterolemia due to toxicity. TARGET/MARKER/PATHWAY: HMG-CoA reductase...
...2018 doi:10.1124/jpet.118.247643 CONTACT: Jaipal Singh, Indiana University School of Medicine, Indianapolis, Ind. email: singh52@iupui.edu Sandi Wong Indiana University HMG-CoA reductase Hypertension...
BioCentury | Aug 11, 2017
Clinical News

Esperion's bempedoic acid combo meets in Phase II for hypercholesterolemia

...is a cholesterol absorption inhibitor from Merck & Co. Inc. (NYSE:MRK), and Lipitor is an HMG-CoA reductase...
BioCentury | Aug 9, 2017
Clinical News

Esperion to raise funds after reporting bempedoic acid LDL-C data

...is a cholesterol absorption inhibitor from Merck & Co. Inc. (NYSE:MRK), and Lipitor is an HMG-CoA reductase...
...Inc. Merck & Co. Inc. Pfizer Inc. ATP citrate lyase (ACLY) Niemann-Pick C1-like protein (NPC1L1) Proprotein convertase subtilisin/kexin type 9 (PCSK9) atorvastatin HMG-CoA reductase...
BioCentury | Jul 13, 2017
Strategy

Everyone counts in GWAS

...retrospective analyses have proven that GWAS hits with small effect sizes, like the statin target HMG-CoA reductase...
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