22:54 , Aug 1, 2019 |  BC Innovations  |  Product Development

NeuBase takes antisense oligos to more targets in more places

Newcomer NeuBase Therapeutics is re-engineering antisense oligos to access a broader range of targets, while simultaneously solving the modality’s dosing and delivery issues. With three approvals since the start of 2016, antisense oligonucleotides (ASOs) have...
20:54 , May 20, 2019 |  BC Innovations  |  Distillery Therapeutics

Brain-penetrating SELP-based peptide for stroke

DISEASE CATEGORY: Neurology INDICATION: Stroke Mouse studies suggest a brain-penetrating SELP-based fusion peptide could help treat stroke. The fusion consists of six amino acids from the C-terminus of SELP, which transports the ferroptosis inhibitor selenium,...
17:37 , Jul 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Cell culture and mouse studies suggest virus-targeted delivery of defective versions of viral RNA polymerase subunits PA, PB1 and PB2 genes could help prevent or treat influenza A infection. In canine and...
20:52 , Oct 20, 2017 |  BC Extra  |  Preclinical News

Inhibition of HIV tat could allow patients to halt ART

A paper published in Cell Reports builds on evidence that suggests inhibiting HIV tat protein (HIV tat) could treat HIV by blocking viral transcription and rebound from latent viral reservoirs. In 2015, a team from...
18:33 , Jul 27, 2017 |  BC Innovations  |  Translation in Brief

Cycling across the membrane

In a Nature Chemistry study, a German team has shown that nanobodies coupled to cyclic peptides rich in arginine can target intracellular proteins with antibody-like precision and even deliver extracellular proteins to the cytosol. Delivering...
16:50 , Jun 20, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Stroke In vitro and mouse studies suggest a peptide inhibitor of the KCNB1 - STX1A interaction could help treat ischemic stroke. In a cultured rat cortical neuronal model of chemical-induced, stroke-related neurotoxicity, a KCNB1-derived...
23:34 , Jun 15, 2017 |  BC Innovations  |  Tools & Techniques

Breaking the barrier

A three-way deal between Amgen Inc. , Feldan Therapeutics Inc. and Elasmogen Ltd. is the latest cause for optimism that technologies are finally converging to enable the generation of cell-penetrating biologics. The biotechs join a...
13:20 , May 9, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Huntington’s disease (HD) In vitro and mouse studies suggest an HIV tat -free, stapled BECN1 -derived peptide that inhibits autophagy could help treat HD and other neurodegenerative diseases. Chemical synthesis and testing in HeLa...
22:41 , Apr 27, 2017 |  BC Innovations  |  Targets & Mechanisms

Selective senescence

A group at the Erasmus University Rotterdam has devised a strategy for inducing apoptosis only in senescent cells, and used it to create a cell-permeable peptide that it hopes to take to the clinic to...
19:07 , Jan 18, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: HIV/AIDS Cell culture studies suggest CRISPR- Cas9 editing of two or three HIV genes could help prevent reactivation of latent HIV in patients. In an HIV-1-infected human cell line expressing Cas9, lentiviral vector-encoded guide...