17:37 , Jul 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Cell culture and mouse studies suggest virus-targeted delivery of defective versions of viral RNA polymerase subunits PA, PB1 and PB2 genes could help prevent or treat influenza A infection. In canine and...
20:52 , Oct 20, 2017 |  BC Extra  |  Preclinical News

Inhibition of HIV tat could allow patients to halt ART

A paper published in Cell Reports builds on evidence that suggests inhibiting HIV tat protein (HIV tat) could treat HIV by blocking viral transcription and rebound from latent viral reservoirs. In 2015, a team from...
18:33 , Jul 27, 2017 |  BC Innovations  |  Translation in Brief

Cycling across the membrane

In a Nature Chemistry study, a German team has shown that nanobodies coupled to cyclic peptides rich in arginine can target intracellular proteins with antibody-like precision and even deliver extracellular proteins to the cytosol. Delivering...
16:50 , Jun 20, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Stroke In vitro and mouse studies suggest a peptide inhibitor of the KCNB1 - STX1A interaction could help treat ischemic stroke. In a cultured rat cortical neuronal model of chemical-induced, stroke-related neurotoxicity, a KCNB1-derived...
23:34 , Jun 15, 2017 |  BC Innovations  |  Tools & Techniques

Breaking the barrier

A three-way deal between Amgen Inc. , Feldan Therapeutics Inc. and Elasmogen Ltd. is the latest cause for optimism that technologies are finally converging to enable the generation of cell-penetrating biologics. The biotechs join a...
13:20 , May 9, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Huntington’s disease (HD) In vitro and mouse studies suggest an HIV tat -free, stapled BECN1 -derived peptide that inhibits autophagy could help treat HD and other neurodegenerative diseases. Chemical synthesis and testing in HeLa...
22:41 , Apr 27, 2017 |  BC Innovations  |  Targets & Mechanisms

Selective senescence

A group at the Erasmus University Rotterdam has devised a strategy for inducing apoptosis only in senescent cells, and used it to create a cell-permeable peptide that it hopes to take to the clinic to...
19:07 , Jan 18, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: HIV/AIDS Cell culture studies suggest CRISPR- Cas9 editing of two or three HIV genes could help prevent reactivation of latent HIV in patients. In an HIV-1-infected human cell line expressing Cas9, lentiviral vector-encoded guide...
07:00 , Sep 1, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Nucleolar protein 3 (NOL3; ARC); HIV tat protein (HIV tat)

Neurology INDICATION: Stroke Mouse and cell culture studies suggest NOL3 could help treat ischemic stroke. In neurons from a mouse model of ischemic stroke, NOL3 levels were lower than in neurons from normal mice. In...
07:00 , Aug 25, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Neurotrophic tyrosine kinase receptor 2 (TrkB; NTRK2)

Neurology INDICATION: Addiction Rat studies suggest that brain-penetrating TrkB antagonists could help treat cocaine addiction. In a rat model of self-administered cocaine addiction, a peptide TrkB inhibitor tool compound fused to the transduction domain of...