00:55 , Feb 14, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: HIV / AIDS Mouse studies identified a prodrug of the HIV integrase inhibitor Tivicay dolutegravir that could help treat HIV infection. The prodrug consists of Tivicay modified with myristic acid for formation of hydrophobic and...
07:00 , Apr 9, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: CC chemokine receptor 5 (CCR5; CD195); transportin 3 (TNPO3)

Infectious disease INDICATION: HIV / AIDS In vitro studies suggest an aptamer-siRNA conjugate that inhibits CCR5 and TNPO3 could help treat HIV infection. The conjugate consisted of an aptamer that bound CCR5 with a Kd of 113...
08:00 , Jan 19, 2015 |  BC Week In Review  |  Clinical News

Alere Determine HIV-1/2 Ag/Ab Combo test regulatory update

FDA granted a CLIA waiver to Alere Determine HIV-1/2 Ag/Ab Combo test from Alere as an aid in diagnosing HIV-1 and HIV-2 infection. The point-of-care test was previously marketed in the U.S. as a CLIA...
08:00 , Dec 12, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease HIV/AIDS CD36 (GPIV) In vitro studies suggest anti-CD36 antibodies could help...
08:00 , Nov 4, 2013 |  BC Week In Review  |  Company News

Alere sales and marketing update

Alere launched its Alere Determine HIV-1/2 Ag/Ab Combo test in the U.S. as an aid in the diagnosis of HIV-1 and HIV-2 infection. FDA approved the test in August, at which time the agency...
07:00 , Oct 7, 2013 |  BC Week In Review  |  Clinical News

SAV001-H: Phase I data

Sumagen and researchers at Western University (London, Ontario) reported data from the double-blind, placebo-controlled, U.S. Phase I SAV-CT01 trial in patients with chronic HIV-1 infection receiving highly active antiretroviral therapy (HAART) showing that intramuscular SAV001-H...
07:00 , Aug 19, 2013 |  BC Week In Review  |  Clinical News

Alere Determine HIV-1/2 Ag/Ab Combo test regulatory update

FDA approved a PMA from Alere for Alere Determine HIV-1/2 Ag/Ab Combo test as an aid in the diagnosis of HIV-1 and HIV-2 infection. The agency said Alere Determine is the first test that simultaneously...
07:00 , Aug 1, 2011 |  BC Week In Review  |  Clinical News

GS HIV Combo Ag/Ab EIA regulatory update

Bio-Rad said FDA approved a PMA for the fourth generation GS HIV Combo Ag/Ab EIA to diagnose HIV infection. The company plans to launch the test by Aug. 29. The enzyme immunoassay detects the HIV...
07:00 , Sep 13, 2010 |  BC Week In Review  |  Company News

Abbott sales and marketing update

Abbott launched its Architect HIV Ag/Ab combo assay in the U.S. to diagnose HIV infection in serum and plasma samples. The chemiluminescent microparticle immunoassay detects both the HIV p24 antigen and antibodies to HIV-1...
07:00 , Aug 19, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease HIV/AIDS Lymphocyte antigen 75 (LY75; DEC205); HIV p24 A study in mice identified DEC205-targeting mAbs...