07:00 , Jul 23, 2015 |  BC Innovations  |  Product R&D

Sealing the envelope

Research from two academic groups could bring HIV vaccines a step closer to the finish line by identifying new ways to stabilize trimers of the HIV envelope protein. The greater stability raises the chances that...
07:00 , Jul 16, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: HIV env; HIV gag polyprotein; HIV pol; HIV gp140

Infectious disease INDICATION: HIV / AIDS Non-human primate studies identified a prime-boost vaccine protocol that could help prevent HIV infection. In a monkey model of SIV infection, two priming immunizations with an adenoviral vaccine encoding...
07:00 , Jul 16, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: HIV gp140; HIV gp120; HIV gp41

Infectious disease INDICATION: HIV / AIDS Animal studies suggest stabilized HIV gp140 trimers could be used to develop vaccines that elicit broadly neutralizing antibodies (bNAbs). Stabilized HIV gp140 trimers were engineered with a disulfide bond...
07:00 , Jul 16, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Stabilizing HIV gp140 trimers for vaccines that elicit broadly neutralizing antibodies (bNAbs) against HIV

Drug platforms HIV gp140 HIV gp120 HIV gp41 National Institutes of Health...
08:00 , Nov 18, 2013 |  BC Week In Review  |  Clinical News

HIV/AIDS vaccine: Additional Phase IIa data

GeoVax reported additional data from the double-blind, placebo-controlled, U.S. and Peruvian Phase IIa HVTN 205 trial in 299 healthy, uninfected volunteers showing that HIV gp140 IgG antibody titers in patients who received the company's HIV-1...
08:00 , Nov 14, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease HIV/AIDS HIV gp120; HIV gp140; tenascin C (TNC; TN) Cell-based studies suggest the human breast milk-derived protein TNC could help prevent HIV-1 infection. In...
01:24 , Jun 16, 2007 |  BC Extra  |  Clinical News

Induction of broadly cross-reactive anti-HIV-1 antibodies

Researchers from the Uniformed Services University of the Health Sciences, GlaxoSmithKline (LSE:GSK; GSK) and the China Center for Disease Control and Prevention reported in the Proceedings of the National Academy of Sciences that immunization with...