BioCentury | Jun 23, 2020
Distillery Therapeutics

An HIV vaccine stimulating T cell and antibody responses

...CATEGORY: Infectious disease INDICATION: HIV/AIDS Adding T cell-stimulating heterologous viral vectors (HVVs) to an adjuvanted, HIV env-based...
...I testing to prevent HIV. TARGET/MARKER/PATHWAY: HIV env; toll-like receptor 7 (TLR7); TLR8; HIV gag polyprotein; HIV env...
...University School of Medicine, Stanford, Calif. e-mail: bpulend@stanford.edu Claire Quang 3M-052, MEDI9197 Stanford University Emory University University of Minnesota HIV gag polyprotein HIV env Toll-like...
BioCentury | May 15, 2020
Translation in Brief

Passage’s mouse, dog data for Krabbe disease; plus a predictive model of COVID-19 mortality, Sorrento’s COVID-19 antibody candidate and more

...and induced stronger antibody and cell-mediated immune responses. Targets CRP - C-reactive protein Env - HIV env...
...Science and Technology Massachusetts Institute of Technology Chinese Academy of Sciences Passage Bio Inc. SARS-CoV-2 spike protein (SARS-CoV-2 S) Galactosylceramidase (GALC) HIV env C-reactive...
BioCentury | Feb 22, 2020
Translation in Brief

Storm's open-access algorithm for RNA epigenetics; plus Duke studies show checkpoint blockers promote anti-HIV bNAbs and reduce opioid efficacy

...in a Nature Communications paper , which was published Wednesday, co-administration of a vaccine delivering HIV env...
BioCentury | Oct 31, 2019
Preclinical News

Oct. 31 Preclinical Quick Takes: Beam licenses tech from Prime Medicine; plus BioVersys, Astellas-Kyoto University and more

...against HIV and other pathogens. In a proof-of-concept study, the researchers designed immunogens based on HIV env...
BioCentury | Oct 25, 2019
Tools & Techniques

Gladstone, Xyphos target universal CARs to latent HIV

...MicAbody CAR-binding domain to the Fc portion of four known broadly neutralizing antibodies (bNAbs) against HIV env...
...is moving forward with autologous therapies as allogeneic cells undergo clinical validation. Sandi Wong, Staff Writer Gladstone Institutes HIV env CAR...
BioCentury | Aug 29, 2019
Distillery Therapeutics

Cytomegalovirus vectors could form the backbone of an HIV vaccine

...RhCMV) vector attenuated to reduce spread and expressing SIV proteins corresponding to HIV gag polyprotein, HIV env...
...Biotechnology Inc. (see "Cytomegalovirus Vectors for a Prophylactic HIV Vaccine" ). TARGET/MARKER/PATHWAY: HIV gag polyprotein; HIV env...
BioCentury | Mar 13, 2019
Distillery Therapeutics

Cocktails of AAV vectors encoding anti-HIV bNAbs to treat the infection

...the model, intramuscular injection of a cocktail of AAV8 vectors encoding bNAbs targeting HIV gp120, HIV env...
...mAb against HIV gp120, in preclinical testing for HIV infection. TARGET/MARKER/PATHWAY: HIV gp41; HIV gp120; HIV env...
...Miami Miller School of Medicine, Miami, Fla. e-mail: r.desrosiers@med.miami.edu Hongjiang Li University of Miami Miller School of Medicine HIV env HIV...
BioCentury | Mar 4, 2019
Distillery Therapeutics

gp120-binding bNAbs for HIV

...culture studies suggest broadly neutralizing antibodies (bNAbs) that bind two adjacent HIV gp120 monomers in HIV env...
...0.06-0.15 μg/mL. Next steps include optimizing the potency of the engineered bNAbs. TARGET/MARKER/PATHWAY: HIV gp120; HIV env...
BioCentury | Dec 19, 2018
Distillery Therapeutics

Infectious disease

...INDICATION: HIV/AIDS Non-human primate studies suggest soluble HIV env trimer given in combination with a saponin-based adjuvant...
...saponin-based adjuvant could help prevent HIV infection. In macaques challenged with HIV, immunization with soluble HIV env...
...include toxicity studies of the combination. Inovio Pharmaceuticals Inc. has Pennvax-GP, a DNA vaccine targeting HIV env...
BioCentury | Oct 25, 2018
Distillery Therapeutics

Infectious disease

...culture and rat studies identified lipopeptide-based inhibitors of MERS-CoV S protein, Ebola virus glycoprotein and HIV env...
...of a conserved region of the viral fusion proteins MERS-CoV S protein, Ebola virus glycoprotein, HIV env...
...or HIV-infected HeLa cells, one of the compounds inhibited Ebola virus glycoprotein-mediated viral entry and HIV env-mediated...
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