07:00 , Apr 4, 2013 |  BC Innovations  |  Cover Story

Closer to class IIa HDAC inhibitors

GlaxoSmithKline plc and its Tempero Pharmaceuticals Inc. spinout have identified selective, first-in-class compounds that bind and inhibit the catalytic domain of class IIa histone deacetylase s, 1 a not-so-well-understood subset of the target family that...
07:00 , Oct 11, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease a-Antitrypsin (AAT) deficiency a1-Antitrypsin (AAT; A1AT; SERPINA1); histone deacetylase 7 (HDAC7) In vitro studies suggest suberoylanilide hydroxamic acid (SAHA) could help treat AAT deficiency....
07:00 , Oct 11, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease a-Antitrypsin (AAT) deficiency a1-Antitrypsin (AAT; A1AT; SERPINA1); histone deacetylase 7 (HDAC7) In vitro studies suggest suberoylanilide hydroxamic acid (SAHA) could help treat AAT deficiency....
07:00 , Jun 2, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Histone deacetylase 4 (HDAC4); HDAC5; HDAC7 A study in mice suggests antagonizing the class IIa HDACs-HDAC4, HDAC5 and HDAC7-could help treat type...
08:00 , Jan 7, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Pulmonary disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Pulmonary disease Cystic fibrosis (CF) Histone deacetylase 7 (HDAC7) A study in cell culture suggests that antagonizing HDAC7 could help treat CF. The DF508 mutation of...
08:00 , Jan 7, 2010 |  BC Innovations  |  Cover Story

Reaching the surface in CF

Researchers at The Scripps Research Institute have found that inhibiting histone deacetylase 7 may improve ion transport in the lung cells of patients with cystic fibrosis by helping to properly fold mutant CFTR protein. 1...
08:00 , Jan 7, 2010 |  BC Innovations  |  Cover Story

Reaching the surface in CF

Researchers at The Scripps Research Institute have found that inhibiting histone deacetylase 7 may improve ion transport in the lung cells of patients with cystic fibrosis by helping to properly fold mutant CFTR protein. 1...
08:00 , Jan 8, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Cutaneous T cell lymphoma (CTCL) B cell lymphoma 2 (BCL2; BCL-2) histone deacetylase 7 (HDAC7) An in vitro study suggests...
01:20 , Mar 6, 2007 |  BC Extra  |  Clinical News

Researchers publish Foxp3 mechanism

Researchers from the University of Pennsylvania published a mechanism in The Proceedings of the National Academy of Sciences by which the forkhead family protein Foxp3 helps to repress the transcription of T cells in vivo....