BioCentury | May 4, 2020
Deals

Stemline takeout gives Menarini U.S. oncology beachhead

...and tumor lysis syndrome. Menarini also holds ex-U.S. rights in some territories to pracinostat, an HDAC...
...or Italy following EU approval. Targets FLT3 (CD135) - FMS-like tyrosine kinase 3 HDAC - Histone deacetylase...
BioCentury | Apr 14, 2020
Deals

Expanded deal with Kyowa could give MEI cash through drug approval

...to handle an asset like this.” MEI’s pipeline includes one therapy in Phase III testing, HDAC...
...4 CDK4 - Cyclin dependent kinase 4 CDK6 - Cyclin dependent kinase 6 HDAC - Histone deacetylase...
BioCentury | Mar 26, 2020
Finance

March 25 Quick Takes: Temasek leads Abbisko’s $70M C round; plus IASO and Regenacy

...Targets BCMA (TNFRSF17; CD269) - Tumor necrosis factor receptor superfamily member 17 HDAC6 - Histone deacetylase...
BioCentury | Mar 20, 2020
Emerging Company Profile

Eikonizo: brain-penetrant HDAC inhibitors for neurodegeneration

...None issued Targets HDAC6 - Histone deacetylase 6 SOD1 - Superoxide dismutase 1 Elizabeth S. Eaton, Staff Writer Histone deacetylase...
BioCentury | Feb 22, 2020
Product Development

Regenerative medicine for hearing loss makes quiet progress

...Phase IIa trial of FX-322 in 2H20. The small molecule combination therapy pairs the approved HDAC...
...factor DCC - Deleted in colorectal carcinoma GSK3 - Glycogen synthase kinase 3 HDAC - Histone deacetylase...
...Pharmaceuticals Inc. Otologic Pharmaceutics Inc. Brain-derived neurotrophic factor (BDNF) Atonal homolog 1 (ATOH1) (HATH1) Glycogen synthase kinase 3 (GSK3) Histone deacetylase (HDAC) Hairy...
BioCentury | Jan 30, 2020
Distillery Therapeutics

HDAC3 identified as obesity target

...reduced body weight along with serum triglyceride levels during an oral lipid tolerance test. TARGET/MARKER/PATHWAY: Histone deacetylase...
...Australia email: matt.watt@unimelb.edu CONTACT: John M. Mariadason, same affiliation as above email: john.mariadason@onjcri.org Claire Quang University of Melbourne Histone deacetylase...
BioCentury | Dec 12, 2019

HDAC9 identified as target in atherosclerosis

...reduced aortic calcification by about 40% and extended median survival by about 20 days. TARGET/MARKER/PATHWAY: Histone deacetylase...
...of Veterans Affairs, Boston, Mass. email: Christopher.ODonnell@va.gov Claire Quang Harvard Medical School U.S. Department of Veterans Affairs Massachusetts General Hospital Histone deacetylase...
BioCentury | Dec 2, 2019
Company News

Dec. 2 Regulatory Roundup: Chipscreen’s approval; plus Priority Review for new Imfinzi, Keytruda indications; EMA reviewing Orchard, Amarin candidates; and more

...review a total of four applications. China’s National Medical Products Administration extended the label of HDAC...
...ACVR2B - Activin receptor type 2B; EZH2 - Enhancer of zeste homolog 2; HDAC - Histone deacetylase...
BioCentury | Nov 21, 2019

Entinostat-derived LSD1 and HDAC dual inhibitor for pediatric glioma

...of pediatric brain cancer. A dual HDAC and LSD1 inhibitor tool compound, derived from the HDAC...
...for gastrointestinal tumors and Phase I/II for melanoma. TARGET/MARKER/PATHWAY: Lysine-specific demethylase 1 (LSD1; KDM1A); Histone deacetylase (HDAC...
...Mass. email: yang_shi@hms.harvard.edu Claire Quang entinostat (KHK2375, SNDX-275, ms-275) Dana-Farber Cancer Institute Harvard Medical School Lysine-specific demethylase 1 (LSD1) (KDM1A) Histone deacetylase (HDAC...
BioCentury | Nov 19, 2019
Company News

Alkermes expands CNS pipeline with Rodin acquisition

...A mix of preclinical and clinical data spurred Alkermes' takeout of Rodin, which adds HDAC-targeting programs...
...front and up to $850 million in milestones. Under the deal, Alkermes gains Rodin's selective HDAC...
...and chemistry work showing that Rodin's selective HDAC inhibitors avoided the hematologic toxicities associated with pan-HDAC...
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