14:42 , Dec 11, 2018 |  BC Innovations  |  Distillery Therapeutics

Inflammation

INDICATION: Inflammatory disease Cell culture studies suggest combined inhibition of BRD4 and HDAC could help treat type I interferon-driven diseases. In fibroblasts from patients deficient in the type I interferon regulators ISG15 or USP18, a...
19:12 , Dec 7, 2018 |  BC Week In Review  |  Financial News

Salubris leads Viracta venture round, gets Chinese rights to cancer therapy

Shenzhen Salubris Pharmaceuticals Co. Ltd. (SZSE:002294) led a series C round for Viracta Therapeutics Inc. (San Diego, Calif.) on Dec. 4 and gained Chinese rights to develop Viracta’s nanatinostat (VRx-3996) in combination with an antiviral...
20:33 , Dec 6, 2018 |  BC Innovations  |  Translation in Brief

Opening chromatin: long-term detriment?

An Institute for Research in Biomedicine team has shown increasing chromatin accessibility in cancer could promote tumor aggressiveness, not reduce tumor mutation burden (TMB) as previously thought. The findings, reported last month in Nature Cell...
21:29 , Dec 4, 2018 |  BC Extra  |  Financial News

Salubris leads Viracta venture round, gets Chinese rights to cancer therapy

Shenzhen Salubris Pharmaceuticals Co. Ltd. (SZSE:002294) led a series C round for Viracta Therapeutics Inc. (San Diego, Calif.) on Tuesday and gained Chinese rights to develop Viracta’s nanatinostat (VRx-3996) in combination with an antiviral to...
20:10 , Nov 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample, cell culture and mouse studies suggest miR-584-5p could help treat medulloblastoma. In patient tissue samples or tumor cells from patient-derived xenograft (PDX) mouse models of medulloblastoma, miR-584-5p levels were lower...
18:51 , Nov 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Cell culture and mouse studies suggest inhibiting HDAC3 could help treat AD. In a HEK cell line expressing mutant APP, a tool compound HDAC3 inhibitor decreased levels of neurotoxic β amyloid...
18:49 , Nov 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Leukemia; multiple myeloma (MM) Cell studies identified a dual HDAC6/proteasome inhibitor that could help treat leukemia and MM. A chemical reaction coupling a N-hydroxybenzamide-based HDAC inhibitor to a tris(oxo-4-phenylbutan-2-ylamino)-based proteasome inhibitor yielded a compound...
04:47 , Nov 9, 2018 |  BC Innovations  |  Tools & Techniques

HitGen’s DNA for small molecules

With more than 60 partnerships under its belt, HitGen Ltd. has become a major gateway for companies to access DNA-encoded library technology -- a high efficiency form of combinatorial chemistry that upstages high throughput screening....
19:50 , Nov 2, 2018 |  BC Week In Review  |  Clinical News

Syndax's entinostat misses PFS endpoint in Phase III for breast cancer

Syndax Pharmaceuticals Inc. (NASDAQ:SNDX) reported that entinostat (SNDX-275) missed the primary endpoint of improving progression-free survival (PFS) in the Phase III E2112 trial to treat breast cancer. The company said the trial will continue as...
17:37 , Oct 26, 2018 |  BC Extra  |  Clinical News

Syndax slides on entinostat PFS miss in breast cancer

Syndax Pharmaceuticals Inc. (NASDAQ:SNDX) fell $1.03 (17%) to $5.01 Friday after reporting late Thursday that entinostat missed the primary endpoint of improving progression-free survival in the Phase III E2112 trial to treat breast cancer. The...