BioCentury | Jun 1, 2019
Product Development

ASCO 2019 abstracts show solid tumor race heating up among bispecifics and CAR Ts

While strong progress in CAR T therapies will again feature at this year’s ASCO meeting, bispecific antibodies are having a moment -- making more inroads into solid tumors than CAR Ts and branching out via...
BioCentury | May 20, 2019
Distillery Therapeutics

HIST4H4 inhibition to treat atherosclerosis

DISEASE CATEGORY: Cardiovascular INDICATION: Atherosclerosis Mouse studies suggest inhibiting HIST4H4 or its interaction with the cell membrane could help treat atherosclerosis. In a mouse model of atherosclerosis, a mAb against HIST4H4 or a cyclical peptide...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

While it’s no surprise that cell therapy research is dominant in hematology, the emergence of epigenetics as an equally large focus at this year’s ASH meeting is more notable, reinforcing the resurgence of a field...
BioCentury | Jul 28, 2017
Regulation

Ganging up in rare disease

A joint proposal from EMA and FDA that encourages companies to join multidrug platform trials for pediatric Gaucher’s disease came too late to serve its original purpose. But the proposal could provide a template for...
BioCentury | Nov 9, 2016
Distillery Therapeutics

Cancer

INDICATION: Breast cancer; cancer Patient sample, cell culture and mouse studies suggest promoting H1.0 expression could help treat breast and other cancers. In patients with 19 types of cancer, low tumors levels of H1.0 correlated...
BioCentury | Apr 11, 2013
Distillery Therapeutics

Indication: Cancer

...Licensing status Publication and contact information Cancer Brain cancer H3 histone family 3A (H3.3A; H3F3A); histone cluster 1 H3b (HIST1H3B)...
...complex 2 (PRC2) In vitro and cell culture studies identified gain-of-function mutations in H3F3A and HIST1H3B...
...that could be targeted to treat pediatric glioblastoma. The K27M mutation in either H3F3A or HIST1H3B...
BioCentury | Sep 30, 2010
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Nerve damage Histone cluster 1 H1A (HIST1A1; HIST1) A study in mice suggests that HIST1 may help treat nerve damage. In a mouse model of...
BioCentury | Nov 19, 2009
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Sepsis Histone cluster 4, H4 (HIST4H4) Studies in cell culture and in mice suggest that blocking HIST4H4 could help treat sepsis. Mice injected with...
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