BioCentury | Apr 6, 2017
Translation in Brief

Humabodies come of age

...membrane antigen ( PSMA ; FOLH1 ; GCPII). Crescendo is developing the compound, dubbed BiParatopic PSMA-HDC...
BioCentury | Apr 15, 2016
Company News

CV/NASH play Madrigal finds public path via Synta merger

...treat non-small cell lung cancer (NSCLC). The company's assets also include preclinical Hsp90-inhibitor drug conjugate (HDC...
BioCentury | Oct 22, 2015
Clinical News

Synta halting ganetespib study after futility analysis

...new safety signals in GALAXY-2. Synta's pipeline also includes STA-12-8666 , a Hsp90-inhibitor drug conjugate (HDC...
BioCentury | Mar 10, 2014
Clinical News

Synta preclinical data

...the Study of Lung Cancer meeting in Santa Monica. STA-9183 is an Hsp90-inhibitor drug conjugate (HDC...
...Synta launched its HDC platform last year and expects to begin clinical testing of lead HDC...
...compounds in 2015 (see BioCentury, Sept. 16, 2013). Synta Pharmaceuticals Corp. (NASDAQ:SNTA), Lexington, Mass. Product: HDC...
BioCentury | Mar 10, 2014
Clinical News

Synta preclinical data

...the Study of Lung Cancer meeting in Santa Monica. STA-12-8666 is an Hsp90-inhibitor drug conjugate (HDC...
...Synta launched its HDC platform last year and expects to begin clinical testing of lead HDC...
...compounds in 2015 (see BioCentury, Sept. 16, 2013). Synta Pharmaceuticals Corp. (NASDAQ:SNTA), Lexington, Mass. Product: HDC...
BioCentury | Jan 30, 2014
Translation in Brief

Translational tidbits

...at a shuttered pharma facility in Constance, Germany. The new center- Hit Discovery Constance GmbH (HDC)-is...
...LDC), the Centre for Drug Design and Discovery (CD3) in Leuven and Milan's Axxam S.p.A. HDC...
...that HDC will primarily provide screening services for academic clients recruited by CD3 and LDC. HDC's...
BioCentury | Sep 16, 2013
Tools & Techniques

Conjugation for concentration

...The company expects to submit its first IND from the program in 18 months. Each HDC...
...the payload is released, it happens in a cancer cell. In the normal tissue, the HDC...
...said ADC payloads need to have at least picomolar activity to kill target cells, whereas HDC...
BioCentury | Sep 16, 2013
Company News

Synta cancer news

...Synta launched its Hsp90-inhibitor drug conjugate (HDC) platform for cancer therapies. HDCs consist of an inhibitor...
BioCentury | Oct 31, 2011
Regulation

Lessons from PSA debate

...detecting prostate cancer than PSA and digital rectal examination. In addition, unpublished data show "the HDC...
BioCentury | Dec 8, 2008
Clinical News

BF-Derm1: Completed Phase II enrollment

...8 weeks. Biofrontera AG (Xetra:B8F), Leverkusen, Germany Product: BF-Derm1 Business: Dermatology Molecular target: Histidine decarboxylase Description: Histidine decarboxylase...
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