BioCentury | Nov 6, 2020
Targets & Mechanisms

Data Byte: newly identified host factors that regulate ACE2 expression

...and Harvard scientists published data in Cell last month showing that HMGB1...
...22 COMMD3 – COMM domain containing 3 HMGB1High mobility group box 1 NRP1...
...enzyme 2 (ACE2) Transmembrane protease serine 2 (TMPRSS2) High mobility group box 1 (HMGB1) COMM...
BioCentury | Apr 30, 2020
Distillery Therapeutics

Heparan sulfate for prevention of acetaminophen-induced acute liver failure

...HMGB1 than healthy individuals. In mice with acetaminophen overdose, the heparan sulfate polysaccharide, which bound HMGB1...
...a soluble recombinant human thrombomodulin α, for disseminated intravascular coagulation (DIC) in sepsis. TARGET/MARKER/PATHWAY: High mobility group box 1 (HMGB1...
...at Buffalo, Buffalo, N.Y. email: dingxu@buffalo.edu Claire Quang University of North Carolina at Chapel Hill University at Buffalo High mobility group box 1 (HMGB1...
BioCentury | Dec 6, 2019
Targets & Mechanisms

Emerging immuno-oncology mechanisms at ASH 2019

Researchers are finding new ways to monitor the immune system in hematologic diseases that could have implications for optimizing immuno-oncology therapies, according to BioCentury’s analysis of emerging targets at ASH 2019. In abstracts released ahead...
BioCentury | Oct 17, 2019
Emerging Company Profile

Parker Institute’s ArsenalBio launches with $85M to build cell engineering war chest

ArsenalBio launched Thursday with $85 million in a series A round to combine the technologies of its six Parker Institute co-founders into a suite of tools the company thinks could overcome key hurdles to cell...
BioCentury | Dec 19, 2018
Distillery Therapeutics

Neurology

...INDICATION: Cognitive dysfunction Patient sample and mouse studies suggest inhibiting HMGB1 or reactive oxygen species (ROS...
...Applied Immunotherapeutics also has the anti-HMGB1 mAb 2G7 in preclinical testing for anemia. TARGET/MARKER/PATHWAY: High mobility group box 1 (HMGB1...
...email: dhackam1@jhmi.edu CONTACT: Chhinder P. Sodhi, same affiliation as above email: csodhi@jhmi.edu Claire Quang Johns Hopkins University High mobility group box 1 (HMGB1) Cognitive...
BioCentury | Nov 26, 2018
Distillery Therapeutics

Neurology

...treat status epilepticus. In a rat model of lithium-pilocarpine-induced status epilepticus, glycyrrhizin -- which inhibits HMGB1...
...2G7, a mAb against HMGB1, in preclinical testing for anemia of chronic disease. TARGET/MARKER/PATHWAY: High mobility group box 1 (HMGB1...
...The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China email: liyajun9@hotmail.com Claire Quang Xi'an Jiaotong University High mobility group box 1 (HMGB1) Seizures...
BioCentury | May 1, 2018
Distillery Therapeutics

Musculoskeletal

...HMGB1 after muscle injury and in additional models of both bone and muscle damage. TARGET/MARKER/PATHWAY: High mobility group box 1...
...after muscle injury and in additional models of both bone and muscle damage. TARGET/MARKER/PATHWAY: High mobility group box 1 (HMGB1...
...email: marc.feldmann@kennedy.ox.ac.uk CONTACT: Jagdeep Nanchahal, same affiliation as above email: jagdeep.nanchahal@kennedy.ox.ac.uk Jaime De Leon University of Oxford High mobility group box 1 (HMGB1) Tissue...
BioCentury | Jul 28, 2017
Company News

Feinstein grants Applied Immunotherapeutics rights to HMGB1 candidates

...to three preclinical candidates. Applied Immunotherapeutics gained rights to 2G7 , a mAb against high mobility group box 1 (HMGB1...
...The company also gained rights to K557 and K883 , both small molecule inhibitors of HMGB1...
...Inc. , Morris, Conn. Business: Autoimmune, Inflammation Alex Himes Applied Immunotherapeutics Inc. Feinstein Institute for Medical Research Karolinska Institute High mobility group box 1 (HMGB1) 2G7 K557 K883...
BioCentury | Jun 20, 2017
Distillery Therapeutics

Neurology

...suggest HMGB1 could help treat white matter stroke. In oxygen- and glucose-deprived primary mouse oligodendrocytes, HMGB1...
...compared with vehicle. Next steps could include testing HMGB1 in the stroke models. TARGET/MARKER/PATHWAY: High mobility group box 1 (HMGB1...
...Byung Gon Kim, Ajou University School of Medicine, Suwon, South Korea email: kimbg@ajou.ac.kr Hongjiang Li Ajou University High mobility group box 1 (HMGB1...
BioCentury | Aug 18, 2016
Distillery Therapeutics

Therapeutics: High mobility group box 1 (HMGB1)

...and cell culture studies suggest inhibiting HMGB1 could help treat age-related neuroinflammation. Hippocampal levels of HMGB1...
...aged rats than in young rats. In microglia isolated from aged rats, pretreatment with an HMGB1...
...vehicle injection. Next steps could include testing HMGB1 in other models of neuroinflammation. TARGET/MARKER/PATHWAY: High mobility group box 1 (HMGB1...
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