BioCentury | May 3, 2012
Distillery Therapeutics

Indication: Hematology

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Thalassemia Hepcidin antimicrobial peptide (HAMP); transmembrane protease serine 6...
...model of b-thalassemia, Tmprss6 knockout increased mRNA levels of the iron metabolism and storage regulator Hamp...
BioCentury | Nov 17, 2011
Distillery Therapeutics

Indication: Hematology

...This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Hematology Hepcidin antimicrobial peptide (HAMP)...
...carrier family 40 iron-regulated transporter member 1 (SLC40A1; SLC11A3) In vitro and mouse studies suggest HAMP...
...and computational studies identified small HAMP peptides and peptidomimetics (minihepcidins) as HAMP agonists. In a Hamp-deficient...
BioCentury | Dec 9, 2010
Distillery Therapeutics

Indication: Neurology

...Licensing status Publication and contact information Neurology Thalassemia Hepcidin antimicrobial peptide (HAMP) Mouse studies suggest that HAMP or HAMP...
...agonists could help treat b-thalassemia. Compared with healthy controls, b-thalassemia patients have low levels of HAMP...
...protein that regulates iron metabolism and storage. In mouse models of b-thalassemia, transgenic mice overexpressing Hamp...
BioCentury | Nov 22, 2010
Company News

Isis, Xenon deal

...treat anemia of inflammation. Isis will discover candidates against hemochromatosis type 2 juvenile (HFE2) and hepcidin antimicrobial peptide (HAMP)...
BioCentury | Nov 17, 2010
Company News

Isis, Xenon in antisense deal

...treat anemia of inflammation. Isis will discover candidates against hemochromatosis type 2 juvenile (HFE2) and hepcidin antimicrobial peptide (HAMP)...
BioCentury | Aug 12, 2010
Distillery Therapeutics

Indication: Cancer

...member 1 (SLC40A1; SLC11A3); hepcidin antimicrobial peptide (HAMP) In vitro and human tissue studies suggest that SLC40A1 and HAMP...
...cancer. In human breast cancer cell lines and breast tumors, SLC40A1 levels were lower and HAMP...
...and metastasis-free survival (p<=0.003). Compared with estrogen receptor-positive breast cancer patients with normal SCL40A1 and HAMP...
BioCentury | Oct 15, 2009
Distillery Therapeutics

Indication: Inflammation

...4 (TLR4) In vitro and mouse studies suggest that inhibiting HAMP could help reduce inflammation. HAMP...
...a role in iron homeostasis. In mouse models of infectious enterocolitis and chronic colitis, a HAMP...
BioCentury | Mar 5, 2009
Distillery Therapeutics

Indication: Hematology

...Hematology Anemia; hemochromatosis Bone morphogenetic protein 6 (BMP6); hemochromatosis (HFE); hemochromatosis type 2 (juvenile) (HFE2); hepcidin antimicrobial peptide (HAMP)...
...second study, mice injected with exogenous BMP6 had higher expression of the iron regulatory hormone Hamp...
BioCentury | Apr 3, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker /pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Glutamate decarboxylase 65 (GAD65) A study of human serum samples suggests that the absence of anti-idiotypic antibodies (anti-Ids)...
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