BioCentury | Oct 24, 2017
Distillery Techniques

Disease models

...promoted blood vessel formation and five genes -- including phospholipase C β 1 (PLCB1) , hemopoietic cell kinase (HCK)...
...Vienna, Austria email: josef.penninger@imba.oeaw.ac.at Mark Zipkin Austrian Academy of Sciences Gap junction protein alpha 1, 43kDa (GJA1) (CX43) (connexin-43) Hemopoietic cell kinase (HCK) MDS1...
BioCentury | May 16, 2013
Distillery Therapeutics

Indication: Cancer

...be useful for treating AML. SAR studies identified an HCK inhibitor with higher specificity for HCK...
BioCentury | Nov 10, 2011
Distillery Therapeutics

Indication: Inflammation

...suggest inhibiting HCK could help treat inflammation. In primary human macrophages, small interfering RNA against HCK...
...scrambled siRNA. Next steps could include identifying an HCK inhibitor or testing the effects of HCK...
BioCentury | Apr 23, 2007
Tools & Techniques

Ranking the kinase kingdom

...in the highly conserved DFG motif at the amino-terminal end of the activation segment: DAPK3, HCK...
BioCentury | Aug 23, 2004
Tools & Techniques

Src sightings

...stopping BCR-Abl signaling at its source, Src inhibitors might function downstream in CML. Lyn and Hck...
...in signaling downstream from BCR-Abl. Thus, Src kinase inhibitors that are active against Lyn and/or Hck...
BioCentury | Oct 28, 2002
Emerging Company Profile

Cytopia: '(J)ust (A)nother (K)inase'

...site, and an ADME program. To illustrate how Chemaphore works, Wilks used the example of HCK...
...absurdly misfolded, unfeasible conformations," Wilks said. Because some conformations represent the same compound, in the HCK...
BioCentury | Sep 9, 2002
Emerging Company Profile

Signase: Src revival

...Signase is looking to target other members of the Src family such as Lck, Lyn, Hck...
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