BC Innovations | Oct 24, 2017
Distillery Techniques

Disease models

TECHNOLOGY: Cell models A biobank of insertional mutagenesis-derived haploid mouse ESCs could be used to link genes to disease-related phenotypes in homogeneous cell populations. The biobank consists of over 100,000 haploid mouse ESCs with genetically...
BC Innovations | May 16, 2013
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML) Hemopoietic cell kinase (HCK) SAR and mouse studies suggest HCK inhibitors could be useful for treating AML....
BC Innovations | Nov 10, 2011
Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation Hemopoietic cell kinase (HCK) In vitro studies suggest inhibiting HCK could help treat inflammation. In primary human macrophages, small interfering RNA against HCK inhibited...
BioCentury | Apr 23, 2007
Tools & Techniques

Ranking the kinase kingdom

After four years of work, researchers at the Wellcome Trust Sanger Institute and colleagues have elucidated the prevalence and signature of somatic mutations in human protein kinases. The findings, recently reported in Nature , have provided...
BioCentury | Aug 23, 2004
Tools & Techniques

Src sightings

Though it is the oldest known and one of the most studied proto-oncogenes, Src has wallowed in relative obscurity as a drug target compared to the developmental successes had by other kinase inhibitors. However, at...
BioCentury | Oct 28, 2002
Emerging Company Profile

Cytopia: '(J)ust (A)nother (K)inase'

When Andrew Wilks discovered a new group of kinases in 1989 while looking for cytokine receptors, he wanted to call them JAK kinases for "just another kinase," because they weren't what he was looking for....
BioCentury | Sep 9, 2002
Emerging Company Profile

Signase: Src revival

The current popularity of kinases seems to have vindicated Andy Warhol's dictum that just about everyone gets to enjoy 15 minutes of fame. Almost every new addition to the kinase superfamily is touted as the...
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