BioCentury | Nov 21, 2020
Product Development

How Forma is working to show the sickle cell community it’s in for the long haul

...RBCs) in a way that improves both hemoglobin...
...to reducing VOC crises, to now improving hemoglobin...
...which are primarily geared at addressing the hemoglobin...
BioCentury | Nov 17, 2020
Deals

Nov. 16 Quick Takes: Roche-Lead in immunology deal; plus TNBC approval for Keytruda and Apellis, BMS, BeyondSpring, Start Codon, Myricx and PureTech

...to the company. In a Phase III study, the C3 inhibitor led to significant improvements in hemoglobin...
BioCentury | Nov 14, 2020
Product Development

ASH 2020 snapshot: efficacy data in hot emerging areas

...by modulating the oxygen affinity of mutant hemoglobin...
...Blood to pioneer the surrogate endpoint of increased blood  hemoglobin...
...health, including levels of different types of hemoglobin...
BioCentury | Nov 13, 2020
Product Development

Next-generation sickle cell readouts at ASH: Data Byte

...geared to prevent sickling in the first place by modulating the oxygen affinity of mutant hemoglobin...
...That mechanism of action led Global Blood to pioneer the surrogate endpoint of increased blood  hemoglobin...
...similarly reporting readouts showing biochemical improvements in RBC health, including levels of different types of hemoglobin...
BioCentury | Oct 3, 2020
Translation in Brief

A SARS-CoV-2 genome degrader; neutralizing influenza B mAbs; Fulcrum’s sickle cell therapy increases fetal hemoglobin and more

...begin by year-end Phase I testing of FTX-6058, showed that the sickle cell disease therapy elevated fetal hemoglobin...
BioCentury | Sep 16, 2020
Emerging Company Profile

Graphite launches with $45M series A to use CRISPR-Cas9 for targeted gene integration

...the problem. Rather than correcting the faulty hemoglobin...
...production of a different hemoglobin protein, fetal hemoglobin...
BioCentury | Sep 4, 2020
Product Development

Akebia’s prospects dim after safety readout in non-dialysis CKD patients

...to Aranesp based on mean change in hemoglobin...
BioCentury | Jun 13, 2020
Product Development

Additional durability data build confidence for gene editing, gene therapies in hemoglobinopathies

...a severe form of transfusion-dependent β thalassemia remained transfusion independent at 15 months with total hemoglobin...
...total hemoglobin levels of 12.5 g/dL. According to the Mayo Clinic, the normal range for hemoglobin...
...the engineered version of hemoglobin delivered by LentiGlobin accounted for at least 40% of total hemoglobin...
BioCentury | May 12, 2020
Deals

bluebird hopes tough choices today will keep core programs on track

...and globin response will be secondary (see “Sickle Cell Disease Poised for Fresh Infusion of Hemoglobin-Based...
BioCentury | May 2, 2020
Translation in Brief

ORIC’s CD73 inhibitor for cancer; plus Beam, CRISPR-Cas13 for respiratory infections, COVID-19 complex structure, and more

...base editors to correct the HBB point mutation that causes sickle cell, and boosted fetal hemoglobin...
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