BioCentury | Feb 6, 2018
Distillery Therapeutics

Cancer

...inhibiting HHAT could help treat colorectal cancer. In colorectal cancer cells from patients, siRNA targeting HHAT...
...Bayer AG could include identifying and testing HHAT inhibitors in models of colorectal cancer. TARGET/MARKER/PATHWAY: Hedgehog acyltransferase (HHAT)...
...AG, Berlin, Germany email: joseph.regan@charite.de CONTACT: Martin Lange, same affiliation as above email: martin.lange@bayer.com Winnie Pong Bayer AG Hedgehog acyltransferase (HHAT)...
BioCentury | Mar 7, 2013
Distillery Therapeutics

Indication: Cancer

...SHH); smoothened (SMO) In vitro studies identified HHAT inhibitors that could help treat SHH-driven cancers. HHAT...
...alternative way to target the cancer-associated pathway. A high throughput screen identified hits that inhibited HHAT...
...lines, the lead inhibitor decreased SHH signaling compared with vehicle. Next steps include testing the HHAT...
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