BioCentury | Mar 7, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: February 2019

...BioCentury Archives Indication Target Description Company or Institution Notes Therapeutic targets Autoimmune disease Multiple sclerosis HECT domain containing E3 ubiquitin protein ligase 3 (HECTD3)...
BioCentury | Jan 18, 2018
Translation in Brief

A notch for tankyrase

New York University School of Medicine researchers have identified a multitude of tankyrase targets, including factors in the Notch and Wnt/β-catenin pathways, that offer new opportunities for tankyrase inhibitors in cancer. In a Nature Communications...
BioCentury | Aug 13, 2015
Distillery Therapeutics

Therapeutics: HECT domain containing E3 ubiquitin protein ligase 2 (HECTD2)

Inflammation INDICATION: Inflammation; pulmonary Mouse studies suggest inhibiting HECTD2 could help treat lung inflammation. In a mouse model of pneumonia, pretreatment with a lentiviral vector encoding HECTD2 increased lung inflammation compared with a control vector,...
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