BioCentury | Mar 7, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: February 2019

New Therapeutic Targets and Biomarkers: February 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during February. Therapeutic targets are defined as any protein, gene or other molecule...
BioCentury | Mar 1, 2019
Translation in Brief

Targeting pathogenic Th17 cells

A recent pair of studies offers two new approaches to treating autoimmune diseases that go after the source of Th17-mediated inflammation. T helper type 17 (Th17) cells are effector T cells that secrete the cytokine...
BioCentury | Jan 18, 2018
Translation in Brief

A notch for tankyrase

...were not known targets of the enzymes -- naked cuticle homolog 1 (NKD1), NKD2 and HECT domain containing E3 ubiquitin protein ligase 1...
BioCentury | Aug 13, 2015
Distillery Therapeutics

Therapeutics: HECT domain containing E3 ubiquitin protein ligase 2 (HECTD2)

Inflammation INDICATION: Inflammation; pulmonary Mouse studies suggest inhibiting HECTD2 could help treat lung inflammation. In a mouse model of pneumonia, pretreatment with a lentiviral vector encoding HECTD2 increased lung inflammation compared with a control vector,...
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