BioCentury | Aug 8, 2018
Distillery Therapeutics

Cancer

...INDICATION: Acute lymphoblastic leukemia (ALL) Cell culture and mouse studies suggest inhibiting HSF1 could help treat...
...control shRNA. In two mouse models of T cell ALL, systemic HSF1 knockout or tumor-specific HSF1...
...leukemic cell numbers and increased survival compared with normal HSF1 expression. Next steps include studying HSF1...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

...HSP90 CDC37 PTGES3 Protein folding Stress response DNAJ; AR-V7 ATF6 AR-V7-expressing CRPC 2901 DNAJ; AR-V7 HSF1...
BioCentury | Jan 19, 2018
Tools & Techniques

Synthetic expressions

...linked to a hairpin aptamer, which bound a synthetic complex that included the transcriptional activators HSF1...
...4 Cas9 - CRISPR-associated protein 9 FST - Follistatin FXN (FRDA) - Frataxin HSF1 - Heat shock transcription factor 1...
...College London University of Wisconsin-Madison Wisconsin Alumni Research Foundation Bromodomain containing 4 (BRD4) CRISPR-associated protein 9 (Cas9) Dystrophin Follistatin (FST) Frataxin (FXN) (FRDA) Heat shock transcription factor 1 (HSF1) Interleukin-10...
BioCentury | Aug 29, 2017
Distillery Therapeutics

Neurology

...INDICATION: Amyotrophic lateral sclerosis (ALS) Cell culture and mouse studies suggest activating HSF1 could help treat...
...in skeletal muscle, constitutively active HSF1 decreased TDP-43 aggregation compared with normal HSF1 expression or HSF1...
...in spinal cord and brain tissues (see "Unclumping TDP-43." BioCentury Innovations (Aug. 24, 2017)). TARGET/MARKER/PATHWAY: Heat shock transcription factor 1 (HSF1)...
BioCentury | Aug 24, 2017
Translation in Brief

Unclumping TDP-43

...Next, the team tested a therapeutic strategy involving expression of a constitutively activated form of heat shock transcription factor 1 (HSF1)...
...from mouse muscle fibers by inducing proteasome- and autophagy-mediated degradation. Overexpression of proteins downstream from HSF1...
...or DnaJ (Hsp40) homolog subfamily B member 1 (DNAJB1) -- also decreased aggregates. Cohen noted HSF1...
BioCentury | Jul 13, 2015
Company News

Cleveland BioLabs, Bioprocess Capital Ventures deal

...continue to develop the next-generation Curaxin cancer compound, which targets p53, NF-kappa B (NF-kB) and heat shock transcription factor 1 (HSF1)...
BioCentury | Mar 19, 2015
Distillery Therapeutics

Therapeutics: Heat shock transcription factor 1 (HSF1); MEK; proteasome

...knockdown of the proteostatic factor HSF1 increased amyloid levels and decreased viability compared with normal HSF1...
...of amyloids, increased tumor growth and decreased survival compared with vehicle. Next steps could include HSF1...
...or co-inhibition of the proteasome and MEK in cancer cell lines and animal models. TARGET/MARKER/PATHWAY: Heat shock transcription factor 1 (HSF1)...
BioCentury | Jul 10, 2014
Distillery Therapeutics

Indication: Cancer

...vitro and mouse studies suggest inhibiting MLL in combination with HSP90 could help treat cancer. Heat shock transcription factor 1 (HSF1)...
...human cancer cell lines, an siRNA targeting MLL, but not siRNAs targeting related genes, downregulated HSF1-dependent...
BioCentury | Mar 6, 2014
Distillery Therapeutics

Indication: Neurology

...inhibiting Hsp90 could enhance cognitive function. In cultured primary rat neurons, an Hsp90 inhibitor increased heat shock transcription factor 1 (HSF1)-dependent...
BioCentury | Aug 12, 2013
Clinical News

intravenous CBL0137: Phase I started

...NF-kappa B (NF-kB) Description: Next-generation Curaxin anticancer compound which targets p53, NF-kappa B (NF-kB) and heat shock transcription factor 1 (HSF1)...
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