BioCentury | Sep 17, 2020
Product Development

Sept. 16 Quick Takes: AAT deficiency data lift Arrowhead; plus Metacrine’s IPO, Seer spinout and PDUFA dates for Niemann-Pick, burn therapies

...not plan to hold an advisory committee meeting to discuss the small molecule inducer of Hsp70...
...removes nonviable tissue, in adults with thermal burns. The PDUFA date is June 29, 2021.TARGETSHsp70heat shock protein 70 BC...
BioCentury | Apr 3, 2020
Distillery Therapeutics

Depletion of the mitochondrial chaperone HspA9 for BRAF-mutant melanoma

...with BRAF V600 mutation. TARGET/MARKER/PATHWAY: Heat shock 70kDa protein 9 (HspA9; mortalin-2; GRP75); BRAF; heat shock protein 70 (Hsp70...
BioCentury | Nov 21, 2019
Tools & Techniques

Measuring real-time PK/PD by monitoring aberrant chaperone activity

...with the company to develop epichaperome inhibitors for cancer and neurodegenerative diseases. Targets Hsp70 - Heat shock protein 70...
BioCentury | Feb 1, 2019
Clinical News

Orphazyme finds path forward for Niemann-Pick therapy in subgroup data

...approval pathway, with regulatory applications planned in 1H20 for the small molecule inducer of heat shock protein 70 (Hsp70...
...Copenhagen, Denmark Product: Arimoclomol Business: Endocrine/Metabolic Molecular target: Heat shock protein 70 (Hsp70) Description: Small molecule inducer of Hsp70...
...II/III data Milestone: Extension study data (3Q19); submit regulatory applications (1H20) Chris Lieu arimoclomol (BRX-345, OR-01) Orphazyme A/S Heat shock protein 70 (Hsp70) Glycosphingolipid...
BioCentury | Jan 30, 2019
Clinical News

Orphazyme finds path forward for Niemann-Pick therapy in subgroup data

...approval pathway, with regulatory applications planned in 1H20 for the small molecule inducer of heat shock protein 70 (Hsp70...
...the U.S. for NPC, and Orphan Drug designation in the EU. Chris Lieu arimoclomol (BRX-345, OR-01) Orphazyme A/S Heat shock protein 70 (Hsp70) Glycosphingolipid...
BioCentury | Dec 4, 2018
Distillery Therapeutics

Cancer

...Hsp70 inhibitors decreased tumor growth and increased survival. Next steps could include optimizing the two Hsp70...
...small molecule Hsp70 inhibitors CHP-401 and CHP-486 in preclinical testing for bacterial infections. TARGET/MARKER/PATHWAY: Heat shock protein 70 (Hsp70...
...acgao@ucdavis.edu Claire Quang Xtandi, enzalutamide (mdv3100, p-INN) Zytiga (Brand), CB7630 (Compound #), abiraterone acetate (Generic) University of California Davis Heat shock protein 70 (Hsp70) Prostate...
BioCentury | Oct 19, 2018
Clinical News

Orphazyme seeking path forward for arimoclomol in NPC after Phase II/III miss

...with FDA and EMA to determine next steps for the small molecule inducer of heat shock protein 70 (Hsp70...
...Copenhagen, Denmark Product: Arimoclomol Business: Neurology Molecular target: Heat shock protein 70 (Hsp70) Description: Small molecule inducer of Hsp70...
...data Milestone: Final Phase II/III (4Q18); extension study data (2Q19) Jaime De Leon arimoclomol (BRX-345, OR-01) Orphazyme A/S Heat shock protein 70 (Hsp70...
BioCentury | May 30, 2018
Distillery Therapeutics

Cancer

...identified Hsp70 inhibitor decreased tumor volume compared with vehicle, and the DNAJ inhibitor plus the Hsp70...
...small molecule Hsp70 inhibitors, in preclinical testing for bacterial infection. TARGET/MARKER/PATHWAY: DnaJ homolog (DNAJ); heat shock protein 70 (Hsp70...
...#), abiraterone acetate (Generic) National Cancer Institute Androgen receptor Androgen receptor splice variant 7 (AR-V7) DnaJ (Hsp40) homolog (DNAJ) Heat shock protein 70 (Hsp70...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

...cancer (NSCLC) 4362 Protein folding Protein folding DNAJ; AR-V7 DNAJ isoforms AR-V7-expressing CRPC 2901 HSPA4 HSP70...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

...The personalized vaccine, composed of peptide neoantigens from an MM cell line with an added Hsp70...
...ErbB2; neu) - Epidermal growth factor receptor 2 HLA - Human leukocyte antigen Hsp70 - Heat shock protein 70...
...N-methyltransferase 2 (EHMT2) (G9A) Fc gamma receptor III (FCGR3) (CD16) Fc gamma receptor IIIa (FCGR3A) (FcgammaRIIIa) (CD16a) Heat shock protein 70 (Hsp70) Human...
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