BioCentury | Nov 26, 2018
Distillery Techniques

Drug delivery

...line, the construct loaded with an siRNA targeting heat shock 27 kDa protein 1 (HspB1; Hsp27...
...Marseille, France email: ling.peng@univ-amu.fr Jaime De Leon Aix-Marseille University China Pharmaceutical University Heat shock 27 kDa protein 1 (HspB1) (Hsp27) Integrin...
BioCentury | Apr 24, 2018
Distillery Therapeutics

Hematology

...INDICATION: Myeloproliferative disorder Patient sample and mouse studies suggest inhibiting Hsp27 could help treat myelofibrosis (MF...
...Next steps could include identifying and testing Hsp27 inhibitors in models of MF. TARGET/MARKER/PATHWAY: Heat shock protein 27 (Hsp27...
...francois.girodon@chu-dijon.fr CONTACT: Aurélie de Thonel, same affiliation as above email: aurelie.dethonel@univ-paris-diderot.fr Claire Quang University of Bourgogne Franche-Comte Heat shock protein 27 (Hsp27) Myeloproliferative...
BioCentury | Aug 24, 2017
Translation in Brief

Unclumping TDP-43

...by inducing proteasome- and autophagy-mediated degradation. Overexpression of proteins downstream from HSF1 -- namely, heat shock protein 27 (Hsp27...
...program." Nature Communications (2017) Winnie Pong, Staff Writer University of North Carolina University of Zurich DnaJ (Hsp40) homolog (DNAJ) Heat shock protein 27 (Hsp27) Heat...
BioCentury | Nov 10, 2016
Clinical News

Apatorsen: Final Ph II data

...Apatorsen ( OGX-427 ) Business: Cancer Molecular target: Heat shock protein 27 (Hsp27) Description: Second-generation antisense inhibitor of Hsp27...
...bladder cancer Endpoint: Overall survival (OS); safety, overall response rate (ORR), serum levels of Hsp27, Hsp27...
...telomerase activity Status: Final Phase II data Milestone: NA Jaime De Leon apatorsen Ionis Pharmaceuticals Inc. OncoGenex Pharmaceuticals Inc. Heat shock protein 27 (Hsp27...
BioCentury | Sep 29, 2016
Distillery Techniques

Techniques: Panel of 12 hippocampal proteins to diagnose early stage Alzheimer's disease

...3 ( BAG3 , CAIR-1 ), heat shock 27 kDa protein 1 ( HspB1 ; Hsp27...
BioCentury | Apr 4, 2016
Finance

Restructuring watch

...bladder cancer and the Phase II Spruce trial of the second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
BioCentury | Feb 15, 2016
Company News

OncoGenex cancer news

...clusterin mRNA , under an amended 2001 deal. Apatorsen, a second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
BioCentury | Jan 25, 2016
Clinical News

Apatorsen: Phase II data

...Alimta. OncoGenex said a “potential PFS benefit” was observed in patients with high baseline serum Hsp27...
...OGX-427 ) Business: Cancer Molecular target: Heat shock protein 27 (Hsp27) Description: Second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
...NSCLC) Endpoint: Progression-free survival (PFS); overall survival (OS), tumor response rates, safety and effect on Hsp27...
BioCentury | Dec 21, 2015
Clinical News

Apatorsen: Phase II ongoing

...OGX-427 ) Business: Cancer Molecular target: Heat shock protein 27 (Hsp27) Description: Second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
...bladder cancer Endpoint: Overall survival (OS); safety, overall response rate (ORR) and serum levels of Hsp27...
BioCentury | Nov 12, 2015
Product R&D

Crystallin-clear ViewPoint

...researchers screened a library of small molecules to find compounds that reduced the Tm of Hsp27...
...proposed drug candidate lanosterol, but the compound showed weak activity at decreasing the Tm of Hsp27...
...Crystallin α A CRYAB ( HSPB5 ) - Crystallin α B Hsp27 - Heat shock protein 27...
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