13:20 , May 9, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neuropathy In vitro and mouse studies suggest the Hsp72 inducer BGP-15 could help treat familial dysautonomia, a fatal disorder often caused by a point mutation in the IKBKAP gene. In primary IKBKAP-knockout mouse neurons, the...
07:00 , Aug 25, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Heat shock 70 kDa protein 1A (Hsp72; HspA1)

Musculoskeletal disease INDICATION: Musculoskeletal Rat studies suggest the Hsp72-inducer BGP-15 could help treat ventilation-induced diaphragm dysfunction (VIDD). In a mechanically ventilated rat model of VIDD, BGP-15 increased the specific force of diaphragm muscle fibers and myosin force...
07:00 , May 3, 2012 |  BC Innovations  |  Targets & Mechanisms

Heat shock hits muscular dystrophy

Australian academics have used N-Gene Research Laboratories Inc.'s BGP-15, a small molecule inducer of heat shock 70 kDa protein 1A in Phase IIb testing for diabetes, to increase muscle strength and survival in two mouse...
07:00 , Apr 30, 2012 |  BC Week In Review  |  Clinical News

N-Gene preclinical data

In mouse models of DMD, once-daily 15 mg/kg oral BGP-15 significantly reduced whole body muscle breakdown as measured by creatine kinase levels vs. untreated controls (p<0.01). Additionally, BGP-15 for 12 weeks significantly reduced damaged myofibers,...
07:00 , Apr 26, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Muscular dystrophy Heat shock 70 kDa protein 1A (Hsp72; HspA1) ...
07:00 , Sep 18, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer ...
07:00 , Oct 12, 1998 |  BC Week In Review  |  Company News

Stanford University other research news

Stanford researchers published in the Annals of Neurology that injection of a herpes virus vector encoding heat shock protein 72 (HSP72) into rat brains 12 hours prior to injury protected the rats from induced stroke...