08:00 , Dec 17, 2015 |  BC Innovations  |  Tools & Techniques

Heartfelt conversion

A group of Chinese and American researchers have developed the first virus-free cellular reprogramming method that can turn skin cells into cardiac progenitors at an efficiency high enough for clinical use. The U.S. arm is...
08:00 , Dec 3, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Heart and neural crest derivatives expressed 2 (HAND2); myocyte enhancer factor 2C (Mef2c); bone morphogenetic protein 4 (BMP4)

Cardiovascular disease INDICATION: Myocardial infarction (MI) Studies in cells and mice suggest a protein-based method for reprogramming human dermal fibroblasts into cardiac progenitor cells could help regenerate heart tissue after MI. In vitro, incubation of...
07:00 , May 31, 2012 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms In vivo reprogramming of cardiac fibroblasts into cardiomyocytes In vivo conversion of cardiac fibroblasts into cardiomyocytes could help treat heart damage. In mouse tail tip...
07:00 , May 31, 2012 |  BC Innovations  |  Tools & Techniques

Reprogramming heart failure

Two groups at the University of California, San Francisco and The University of Texas Southwestern Medical Center have separately shown that delivering transcription factors directly to the heart reprogrammed cardiac fibroblasts and improved heart function...