BC Innovations | Dec 12, 2019
Distillery Therapeutics

HDAC9 identified as target in atherosclerosis

DISEASE CATEGORY: Cardiovascular INDICATION: Atherosclerosis Inhibiting HDAC9 could treat atherosclerosis by reducing vascular calcification, one of the disease's hallmarks. Six SNPs for which HDAC9 is the nearest gene were associated with abdominal aortic calcification in...
BC Innovations | Mar 27, 2018
Distillery Therapeutics

Cardiovascular

INDICATION: Aneurysm Mouse experiments suggest that inhibiting HDAC9 or the long non-coding RNA (lncRNA) MALAT1 could help treat thoracic aortic aneurysms. In aortic tissue samples from thoracic aortic aneurysm patients, levels of HDAC9 were higher...
BC Innovations | Dec 13, 2016
Distillery Therapeutics

Cancer

INDICATION: Acute lymphoblastic leukemia (ALL); B cell lymphoma Patient sample, cell culture and mouse studies suggest HDAC inhibitors could help treat patients with B cell precursor ALL expressing gene fusions involving MEF2D . Levels of HDAC9...
BC Innovations | Apr 4, 2013
Cover Story

Closer to class IIa HDAC inhibitors

GlaxoSmithKline plc and its Tempero Pharmaceuticals Inc. spinout have identified selective, first-in-class compounds that bind and inhibit the catalytic domain of class IIa histone deacetylase s, 1 a not-so-well-understood subset of the target family that...
BC Innovations | Apr 4, 2013
Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Trifluoromethyloxadiazole (TFMO)-containing compounds to identify class IIa histone deacetylase (HDAC) inhibitors TFMO-containing compounds could be used as research compounds to guide...
BC Innovations | Jan 27, 2011
Cover Story

HDACs get complex

Cellzome AG has reported a chemical proteomic method for determining the selectivity of HDAC inhibitors. The approach makes it possible, for the first time, to determine the effects of an inhibitor on HDACs as components...
BC Extra | Mar 6, 2007
Clinical News

Researchers publish Foxp3 mechanism

Researchers from the University of Pennsylvania published a mechanism in The Proceedings of the National Academy of Sciences by which the forkhead family protein Foxp3 helps to repress the transcription of T cells in vivo....
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