BC Innovations | Nov 14, 2019
Targets & Mechanisms

New roles for HDACs in the cytoplasm and muscle disorders

While HDACs are known for their epigenetic function, NIBR researchers have discovered cytoplasmic HDAC4 substrates involved in muscle physiology. The findings suggest blocking HDAC4 deacetylation activity could treat muscle atrophy and other musculoskeletal disorders. HDACs...
BC Innovations | Apr 4, 2013
Cover Story

Closer to class IIa HDAC inhibitors

GlaxoSmithKline plc and its Tempero Pharmaceuticals Inc. spinout have identified selective, first-in-class compounds that bind and inhibit the catalytic domain of class IIa histone deacetylase s, 1 a not-so-well-understood subset of the target family that...
BC Innovations | Apr 26, 2012
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Ataxia Histone deacetylase 4 (HDAC4) A study in mice suggests blocking the nuclear localization of HDAC4 may help treat ataxia telangiectasia,...
BC Innovations | Jun 2, 2011
Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Histone deacetylase 4 (HDAC4); HDAC5; HDAC7 A study in mice suggests antagonizing the class IIa HDACs-HDAC4, HDAC5 and HDAC7-could help treat type...
BC Innovations | Oct 21, 2010
Distillery Therapeutics

Indication: Musculoskeletal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Muscular atrophy Histone deacetylase 4 (HDAC4); HDAC5 Studies in mice suggest that inhibiting HDAC4 or HDAC5 could help treat neurogenic muscular atrophy. In a...
BC Innovations | Oct 21, 2010
Targets & Mechanisms

Unnerving atrophy

A team at The University of Texas Southwestern Medical Center at Dallas has shown that deletion of class IIa histone deacetylases prevents muscle atrophy after nerve damage. 1 The result suggests that inhibitors of these...
BioCentury | Feb 1, 2010
Emerging Company Profile

Acetylon: Homing in on HDAC6

Acetylon Pharmaceuticals Inc. hopes that by targeting an isoform of histone deacetylase that operates only in diseased cells, its cancer compounds will produce fewer side effects than less specific HDAC inhibitors. The company expects to...
BC Innovations | Jan 7, 2010
Targets & Mechanisms

Targeting miRNAs in ALS

A team from The University of Texas Southwestern Medical Center at Dallas has identified a muscle-specific microRNA-miR-206-that plays a role in the progression of amyotrophic lateral sclerosis. 1 The results suggest that muscle cells could...
BC Innovations | Feb 5, 2009
Distillery Therapeutics

Indication: Cardiovascular disease

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Cardiac hypertrophy; cardiac fibrosis Calcium calmodulin-dependent protein kinase II (CAMK2) Studies in mice suggest that targeting CAMK2 could...
BC Innovations | Jan 22, 2009
Distillery Therapeutics

Indication: Ophthalmic disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Blindness Histone deacetylase 4 (HDAC4) Mouse studies suggest that overexpression of HDAC4 could prevent retinal degeneration and thus treat or...
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