BioCentury | Apr 24, 2018
Distillery Therapeutics

Cancer

...DIPG) and other diffuse midline gliomas harboring the H3.3A K27M mutation. In co-culture with patient-derived H3.3A...
...CAR T cells in Phase I/II testing for neuroblastoma. TARGET/MARKER/PATHWAY: Ganglioside GD2 (GD2); H3 histone family 3A (H3.3A; H3F3A...
...mmonje@stanford.edu CONTACT: Crystal Mackall, same affiliation as above email: cmackall@stanford.edu Chris Lieu Stanford University Ganglioside GD2 (GD2) H3 histone family 3A (H3.3A) (H3F3A) Brain...
BioCentury | Dec 19, 2017
Distillery Techniques

Disease models

...and knockouts Mice with p53 knocked out, ATRX knocked down and both PDGFRA and K27M-mutant H3.3A...
...overexpression of platelet derived growth factor receptor A (PDGFRA; PDGFR2; CD140A) and K27M-mutant H3 histone family 3A (H3.3A; H3F3A...
...London, U.K. email: p.salomoni@ucl.ac.uk Winnie Pong McGill University University College London Alpha thalassemia/mental retardation syndrome X-linked (ATRX) (RAD54) H3 histone family 3A (H3.3A) (H3F3A) Platelet...
BioCentury | Dec 19, 2017
Distillery Therapeutics

Cancer

...H3.3A K27M-mutant human glioma cells, T cells engineered to express a TCR targeting the mutant H3.3A...
...could include testing the cells in additional models of H3.3A K27M-mutant glioma. TARGET/MARKER/PATHWAY: H3 histone family 3A (H3.3A; H3F3A...
...of California San Francisco, San Francisco, Calif. email: hideho.okada@ucsf.edu Mark Zipkin University of California San Francisco H3 histone family 3A (H3.3A) (H3F3A) T...
BioCentury | May 9, 2013
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer H3 histone family 3A (H3.3A; H3F3A); v-myc...
...pediatric and young adult patients with H3F3A-driven glioblastoma. In a glioblastoma cell line with G34-mutant H3F3A...
BioCentury | Apr 11, 2013
Distillery Therapeutics

Indication: Cancer

...therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer H3 histone family 3A (H3.3A; H3F3A...
...polycomb repressive complex 2 (PRC2) In vitro and cell culture studies identified gain-of-function mutations in H3F3A...
...and HIST1H3B that could be targeted to treat pediatric glioblastoma. The K27M mutation in either H3F3A...
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