BioCentury | Aug 23, 2018
Distillery Techniques

Assays and screens; imaging; drug properties

...H2AFX indicate the siRNA-targeted gene could contribute to PARP inhibitor resistance, and increases in phosphorylated H2AFX...
...with the PARP inhibitor Lynparza olaparib, siRNA targeting poly(ADP-ribose) glycohydrolase (PARG) decreased levels of serine139-phosphorylated H2AFX...
...targeting genes in the stem cell factor (SCF; c-Kit ligand; KITLG) complex increased serine139-phosphorylated histone H2AFX...
BioCentury | Apr 23, 2009
Distillery Therapeutics

Indication: Various

...prematurity H2A histone family, member X (H2AFX; H2AX) A study in mice suggests that inhibiting H2AFX...
...help treat cancer, diabetic retinopathy, retinopathy of prematurity and other diseases associated with hypoxia-induced neovascularization. H2afx...
...a mouse model of lung carcinoma, tumor growth rate and neovascularization were significantly lower in H2afx...
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