BioCentury | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

...synthase/hydrolase RelA ( M. tuberculosis RelA) Cell culture and mouse studies suggest inhibiting M. tuberculosis RelA...
BioCentury | Apr 10, 2019
Distillery Therapeutics

Inhibiting bacterial RelA to enhance isoniazid sensitivity in tuberculosis

...of isoniazid compared with normal RelA expression or vehicle. In a mouse model of TB, RelA...
...second mouse model of TB, RelA knockout increased survival. Next steps could include testing the RelA...
...mouse models of chronic-phase TB. TARGET/MARKER/PATHWAY: Mycobacterium tuberculosis bifunctional (p)ppGpp synthase/hydrolase RelA ( M. tuberculosis RelA...
BioCentury | Oct 3, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: September 2018

...Cell culture studies suggest inhibition of P. aeruginosa sodB or combined inhibition of P. aeruginosa relA...
...bacteria and prevent drug resistance. McGill University Distillery Therapeutics P. aeruginosa GTP pyrophosphokinase ( P. aeruginosa relA...
BioCentury | Sep 26, 2018
Distillery Therapeutics

Infectious disease

...Cell culture studies suggest inhibition of P. aeruginosa sodB or combined inhibition of P. aeruginosa relA...
...TARGET/MARKER/PATHWAY: Pseudomonas aeruginosa superoxide dismutase ( P. aeruginosa sodB); P. aeruginosa GTP pyrophosphokinase ( P. aeruginosa relA...
...Dao Nguyen, McGill University, Montreal, Quebec email: dao.nguyen@mcgill.ca Michael J. Haas McGill University Pseudomonas aeruginosa GTP pyrophosphokinase (P. aeruginosa relA) Pseudomonas...
BioCentury | Jan 19, 2018
Tools & Techniques

Synthetic expressions

...a hairpin aptamer, which bound a synthetic complex that included the transcriptional activators HSF1 and RELA...
...shock transcription factor 1 IL-10 - Interleukin-10 PDX1 (IPF1) - Pancreatic and duodenal homeobox 1 RELA...
...1 (HSF1) Interleukin-10 (IL-10) Pancreatic and duodenal homeobox 1 (PDX1) (IPF1) Utrophin (UTRN) V-rel reticuloendotheliosis viral oncogene homolog A (RELA...
BioCentury | Oct 2, 2014
Distillery Therapeutics

Indication: Autoimmune disease

...Publication and contact information Autoimmune disease Rheumatoid arthritis (RA) v-Rel reticuloendotheliosis viral oncogene homolog A (RELA...
BioCentury | Mar 27, 2014
Targets & Mechanisms

Insights into ependymoma

...open reading frame 95 ( C11orf95 ) and v-rel reticuloendotheliosis viral oncogene homolog A ( RELA...
...RELA is the principal effector of NF-kB signaling. Thus, the team next examined if C11orf95-RELA...
...Indeed, in mouse forebrain neural stem cells, expression of C11orf95-RELA upregulated NF-kB target genes, whereas RELA...
BioCentury | Mar 13, 2014
Distillery Therapeutics

Indication: Cancer

...Licensing status Publication and contact information Cancer Brain cancer V-rel reticuloendotheliosis viral oncogene homolog A (RELA...
...11 open reading frame 95 (C11orf95) Patient sample and cell culture studies suggest targeting a C11orf95-RELA...
...treat supratentorial ependymomas. Genetic analyses of patient brain tumor samples identified an oncogenic fusion between RELA...
BioCentury | Feb 18, 2013
Clinical News

CAT-1004: Phase I data

...inflammatory diseases Endpoint: Safety; change from baseline in nuclear v-rel reticuloendotheliosis viral oncogene homolog A (RELA...
BioCentury | Oct 11, 2012
Distillery Therapeutics

Indication: Infectious disease

...contact information Infectious disease Gram-positive bacterial infection GTP pyrophosphokinase (relA) In vitro studies identified an inhibitor of relA...
...In vitro studies identified an inhibitor of relA that could help treat Gram-positive bacterial infections. relA...
...called the stringent response. In enzymatic assays, a 2ʹ-deoxyguanosine-based analog of (p)ppGpp, dubbed Relacin, inhibited relA...
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