BC Innovations | Feb 5, 2015
Distillery Techniques

Techniques: Gremlin 1 (GREM1)-positive osteochondroreticular stem cells

Drug platforms TECHNOLOGY: Cell therapy Cell culture and mouse studies have identified GREM1-positive osteochondroreticular stem cells that could help promote bone repair. In marrow stromal cultures, GREM1-positive stem cells had increased clonogenicity compared with mesenchymal...
BC Innovations | Jun 12, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Glioblastoma Gremlin 1 (GREM1) In vitro and mouse studies suggest inhibiting GREM1 could help treat glioblastoma. In human glioma cancer stem cells (CSCs), expression of...
BC Innovations | Oct 10, 2013
Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Atherosclerosis Gremlin 1 (GREM1); macrophage migration inhibitory factor (MIF) In vitro and mouse studies suggest a GREM1 fusion protein could be used to antagonize...
BC Week In Review | Nov 21, 2011
Clinical News

ConfirmMDx for Lung Cancer diagnostic data

Data from sputum samples from 40 NSCLC patients and 52 symptomatic, cancer-free controls showed that using methylation specific PCR to screen for the methylated Ras association domain family 1A (RASSF1A) gene produced 60% sensitivity and...
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