BioCentury | Apr 6, 2021
Distillery Therapeutics

Targeting ferroptosis directly or via CD36 inhibition for melanoma, MM, NSCLC

...ferroptosis directly or by inhibiting membrane glycoprotein CD36...
...could treat melanoma, MM and NSCLC. Low CD36...
...survival compared with either treatment alone.TARGET/MARKER/PATHWAY: CD36 (GPIV)EXPERIMENTAL...
BioCentury | Jun 16, 2020
Finance

Barcelona’s Ona takes aim at metastasis with €30M series A

...2017 paper published in Nature by Aznar-Benitah and colleagues showed that blocking fatty acid receptor CD36...
...high cost of Phase III trials could drive that decision, she said. Paul Bonanos, Associate Editor Ona Therapeutics CD36 (GPIV) metastasis lipid...
BioCentury | Apr 3, 2020
Distillery Therapeutics

Targeting CD36 for melanoma and colorectal cancer

...DISEASE CATEGORY: Cancer INDICATION: Colorectal cancer; melanoma Inhibiting CD36, a scavenger receptor for uptake of long-chain...
...treat colorectal cancer and melanoma. In a mouse models of colorectal cancer and melanoma, Treg-specific CD36...
...patient samples. Arteria S.A. has the CD36 inhibitor AP-5258 in preclinical testing for dyslipidemia. TARGET/MARKER/PATHWAY: CD36 (GPIV)...
BioCentury | Jan 28, 2020
Distillery Therapeutics

Inhibiting CD36 to overcome resistance to Tykerb in HER2-positive breast cancer

...high tumor levels of CD36 were associated with poor overall survival. Gene expression analysis revealed CD36...
...cancer cell lines. An siRNA against CD36 induced apoptosis in the resistant cells and a CD36...
...cancer, mammary-specific CD36 knockout decreased tumor growth and extended median survival; and a mAb against CD36...
BioCentury | May 31, 2019
Company News

Vigeo debuts to reprogram tumor microenvironment

...TSP-1. According to Watnick, TSP-1 is an antitumorigenic protein that binds via two domains to CD36...
...had developed a peptide, ABT-510, that mimicked that activity of TSP-1, but it only hit CD36...
BioCentury | Mar 13, 2019
Distillery Therapeutics

CD36 as a prostate cancer target

...of CD36 was associated with metastasis and poor relapse-free survival, and high copy numbers of CD36...
...an shRNA targeting CD36 decreased proliferation compared with no treatment. In patient-derived prostate organoids, an anti-CD36...
...with normal CD36 expression. In a patient-derived xenograft (PDX) mouse model of prostate cancer, an anti-CD36...
BioCentury | Nov 15, 2018
Product R&D

Tempest takes PPAR alpha into cancer

...metabolism,” said Dubensky. In the fatty oxidation pathway, PPARα also controls expression of FGF21, PDK4, CD36...
...Tempest Therapeutics Inc., San Francisco, Calif. Targets BATF3 - Basic leucine zipper ATF-like transcription factor CD36 (GPIV)...
BioCentury | Jul 25, 2017
Distillery Therapeutics

Infectious disease

...P. falciparum- infected human erythrocytes, parasitic knockdown of PV1 decreased the binding of erythrocytes to CD36...
...Plasmodium PV1 in models of malaria. TARGET/MARKER/PATHWAY: Plasmodium parasitophorous vacuolar protein 1 ( Plasmodium VP1); CD36 (GPIV)...
...2017 doi:10.1038/ncomms16044 CONTACT: Leann Tilley, The University of Melbourne, Parkville, Australia email: ltilley@unimelb.edu.au Hongjiang Li University of Melbourne CD36 (GPIV) Plasmodium...
BioCentury | Mar 8, 2017
Distillery Therapeutics

Neurology

...CD36 expression. Next steps include identifying and testing CD36 inhibitors in models of SCI. TARGET/MARKER/PATHWAY: CD36 (GPIV)...
...of Miami School of Medicine, Miami, Fla email: jlee22@med.miami.edu Hongjiang Li University of Miami Miller School of Medicine CD36 (GPIV)...
BioCentury | Mar 17, 2016
Distillery Therapeutics

Therapeutics: Prosaposin (PSAP); CD36 (GPIV); thrombospondin-1 (TSP-1; THBS1)

...lines, the CD36 ligand TSP-1 increased apoptosis compared with vehicle. In a mouse model of CD36-positive...
...and metastasis to the liver compared with vehicle. In a patient-derived xenograft mouse model of CD36-positive...
...include testing efficacy and safety of the peptide in animal models. TARGET/MARKER/PATHWAY: Prosaposin (PSAP) ; CD36 (GPIV)...
Items per page:
1 - 10 of 34