BioCentury | Jan 23, 2019
Distillery Therapeutics

Neurology

INDICATION: Depression In vitro and mouse studies identified a quinoline-based GLO1 inhibitor that could help treat depression. In vitro screening of a library of metal-binding pharmacophores in an activity assay and optimization of the top...
BioCentury | Apr 18, 2017
Distillery Therapeutics

Neurology

INDICATION: Depression Mouse studies suggest inhibiting GLO1 could help treat depression. In a mouse model of depression, GLO1 knockout or GLO1 inhibitor tool compounds decreased depressive behaviors compared with normal GLO1 expression or vehicle. Also...
BioCentury | May 31, 2012
Cover Story

Channel-tuning neuropathy

An international team has shown that a peptide inhibitor of methylglyoxal treated hypersensitivity to pain in diabetic mice. 1 Although future studies could determine whether the mechanism plays a role in other types of neuropathic...
BioCentury | Aug 22, 2005
Emerging Company Profile

Chroma: Homing in on chromatin

It is widely accepted that dynamic changes in the structure of chromatin - the substance of chromosomes - are involved in gene transcription. Chroma Therapeutics Ltd. is targeting chromatin-modifying enzymes to treat cancer and inflammation with nanomolar...
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