23:28 , Jun 7, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: May 2018

New Therapeutic Targets and Biomarkers: May 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during May 2018. Therapeutic targets are defined as any protein, gene or other...
18:52 , May 30, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies suggest inhibiting UGT8 could help treat basal-like breast cancer. In four human basal-like breast cancer cell lines, shRNA targeting UGT8 decreased cancer cell colony formation compared with...
22:36 , Apr 4, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: March 2018

New Therapeutic Targets and Biomarkers: March 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during March 2018. Therapeutic targets are defined as any protein, gene or other...
23:08 , Mar 20, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Dengue fever; West Nile virus; Zika virus Cell culture studies suggest inhibiting DDOST, GNB2L1, RPS25 or OST could help treat dengue fever, West Nile virus and Zika virus infections. Screening of an siRNA library...
07:00 , May 26, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Plasma and urine levels of heparan sulfate 6-O-sulfotransferase 2 (HS6ST2), chondroitin polymerizing factor 2 (CHPF2) and exostosin-like glycosyltra

Biomarkers TECHNOLOGY: Diagnostic assays A method of scoring plasma and urine levels of HS6ST2 , CHPF2 and EXTL1 could help diagnose metastatic ccRCC. Genome-wide analysis of tissue samples from 481 ccRCC patients identified multiple genes...
07:00 , May 12, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: ST6 β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1); ST6GAL2

Autoimmune disease INDICATION: Rheumatoid arthritis (RA) Mouse studies suggest enhancing sialylation of autoantibodies could help treat RA. Levels of sialylation on RA autoantigen-specific and total IgG Fc were lower in sera from RA patients and...
07:00 , Oct 1, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: S. aureus monofunctional glycosyltransferase

Infectious disease INDICATION: Bacterial infection; Enterococcus; Staphylococcus; Streptococcus In vitro and mouse studies identified bacterial monofunctional glycosyltransferase inhibitors that could help treat bacterial infections. Chemical synthesis and in vitro testing of monosaccharide-based compounds identified two...
07:00 , Jul 30, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Engineered CHO cell platform for producing biologics with human-like glycosylation patterns

Drug platforms TECHNOLOGY: Expression systems A panel of gene-edited CHO cells with altered glycosyltransferase gene expression could be used to produce biologics with homogeneous, human-like glycosylation patterns. The panel of CHO cells was generated by...
08:00 , Mar 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Translation elongation factor P (Efp); bacterial glycosyltransferase EarP

Infectious disease INDICATION: Pseudomonas Cell culture studies suggest inhibiting Efp or EarP could help treat Pseudomonas aeruginosa infection. In a human lung cell line, infection with Efp- or EarP-deficient strains of P. aeruginosa had no...
08:00 , Jan 29, 2015 |  BC Innovations  |  Targets & Mechanisms

Personalized tumor vaccines

Although the jury is in on the role of PD-1 inhibitors in enabling T cell activation in cancer, it is still unclear which tumor epitopes are targeted by the T cells or whether those epitopes...