BioCentury | Jul 26, 2017
Company News

Lilly stretches Olumiant timeline, updates cancer strategy

...CHEK1) Cyclin dependent kinase 4 (CDK4) Cyclin dependent kinase 6 (CDK6) Dihydrofolate reductase (DHFR) Glucagon-like peptide-1 receptor (GLP-1R) (GLP1R) Glycinamide ribonucleotide formyltransferase (GARFT) Insulin-like...
BioCentury | Mar 2, 2017
Clinical News

Pemetrexed RTD regulatory update

...25 mg/mL pemetrexed, an antifolate that inhibits thymidylate synthase , dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT...
...N.J. Product: Pemetrexed RTD ( EP-5101 ) Business: Cancer Julian Zhu pemetrexed RTD Eagle Pharmaceuticals Inc. Dihydrofolate reductase (DHFR) Glycinamide ribonucleotide formyltransferase (GARFT) Thymidylate...
BioCentury | Jan 4, 2017
Clinical News

Pemetrexed RTD regulatory update

...formulation of pemetrexed, an antifolate that inhibits thymidylate synthase , dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT...
...Woodcliff Lake, N.J. Product: Pemetrexed RTD (EP-5101) Business: Cancer Julian Zhu EP-5101 pemetrexed RTD Eagle Pharmaceuticals Inc. Dihydrofolate reductase (DHFR) Glycinamide ribonucleotide formyltransferase (GARFT) Thymidylate...
BioCentury | Sep 5, 2016
Company News

Eli Lilly sales and marketing update

...determination. Alimta is an antifolate that inhibits thymidylate synthase , dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT...
BioCentury | Jul 25, 2016
Company News

Eli Lilly sales and marketing update

...2014). Alimta is an antifolate that inhibits thymidylate synthase , dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT...
BioCentury | Jul 21, 2016
Company News

NICE now backs Alimta maintenance therapy

...is an antifolate that inhibits thymidylate synthase, dihydrofolate reductase ( DHFR ) and glycinamide ribonucleotide formyltransferase ( GARFT...
BioCentury | Feb 22, 2016
Company News

Allergan, Eli Lilly cancer news

...2015). Alimta -- an antifolate that inhibits thymidylate synthase , dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT...
BioCentury | Oct 15, 2015
Distillery Therapeutics

Therapeutics: Glycinamide ribonucleotide formyltransferase (GARFT); folate receptor 1 (FOLR1; FR-α); FOLR2 (FR-β); solute carrier family 46 folate transporter m

...Cancer INDICATION: Cancer Mouse and cell studies identified an inhibitor of GARFT , FOLR1 , FOLR2...
...synthesis and in vitro testing of pyrimidine antifolate thienoyl analogs identified a compound that inhibited GARFT...
...with vehicle. Next steps could include modifying and testing analogs in cancer models. TARGET/MARKER/PATHWAY: Glycinamide ribonucleotide formyltransferase (GARFT...
BioCentury | Jul 20, 2015
Company News

Allergan, Eli Lilly cancer news

...dosing regimens of the antifolate that inhibits thymidylate synthase , dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT...
BioCentury | Jun 22, 2015
Clinical News

Alimta pemetrexed: Phase III final data

...Glycinamide ribonucleotide formyltransferase (GARFT) Description: Antifolate that inhibits thymidylate synthase , dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT...
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