21:03 , Jul 18, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Ovarian cancer Patient sample, cell culture and mouse studies suggest inhibiting GPAT could help treat ovarian cancer. In patients, high tumor levels of GPAT were associated with poor overall survival. In an ovarian cancer cell...
19:35 , Dec 6, 2016 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Lipodystrophy Mouse and cell culture studies suggest inhibiting GPAT3 and/or GPAT4 could help treat congenital generalized lipodystrophy type 2, which is caused by mutations in BSCL2. In a mouse model of the disease, levels of...
01:32 , Dec 19, 2006 |  BC Extra  |  Clinical News

New triglyceride enzyme found

Researchers at Wyeth (WYE) reported in the Proceedings of the National Academy of Sciences the identification of human and mouse genes that encode for Acyl-CoA: glycerol-3-phosphate acyltransferase-3 (GPAT-3), a microsomal enzyme shown to be...