BioCentury | Jul 18, 2017
Distillery Therapeutics

Cancer

...GPAT were associated with poor overall survival. In an ovarian cancer cell line, knockdown of GPAT...
...a GPAT inhibitor, in preclinical testing to treat obesity. TARGET/MARKER/PATHWAY: Glycerol-3-phosphate acyltransferase mitochondrial (GPAT; GPAM...
...Human Factors (IfADo), Dortmund, Germany email: marchan@ifado.de Hongjiang Li Leibniz Research Centre for Working Environment and Human Factors Glycerol-3-phosphate acyltransferase mitochondrial (GPAT) (GPAM)...
BioCentury | Dec 6, 2016
Distillery Therapeutics

Endocrine / Metabolic

...caused by mutations in BSCL2 . In a mouse model of the disease, levels of GPAT...
...the testes were higher than in normal mice. In a BSCL2-deficient Drosophila macrophage-like cell line, GPAT...
...include testing GPAT inhibitors in mouse models of the disease. TARGET/MARKER/PATHWAY: Glycerol-3-phosphate acyltransferase mitochondrial (GPAT; GPAM...
BioCentury | Dec 19, 2006
Clinical News

New triglyceride enzyme found

...of Sciences the identification of human and mouse genes that encode for Acyl-CoA: glycerol-3-phosphate acyltransferase-3 (GPAT-3...
...a microsomal enzyme shown to be key in the synthesis of triglycerides. Although mitochondrial-associated GPAT...
...to account for the majority of GPAT activity in most tissues. The researchers suggested that GPAT-3...
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