BioCentury | Jul 18, 2017
Distillery Therapeutics

Cancer

INDICATION: Ovarian cancer Patient sample, cell culture and mouse studies suggest inhibiting GPAT could help treat ovarian cancer. In patients, high tumor levels of GPAT were associated with poor overall survival. In an ovarian cancer...
BioCentury | Dec 6, 2016
Distillery Therapeutics

Endocrine / Metabolic

...INDICATION: Lipodystrophy Mouse and cell culture studies suggest inhibiting GPAT3 and/or GPAT4 could help treat congenital...
...GPAT3 or GPAT4 knockdown decreased the size of lipid droplets compared with normal GPAT3 and GPAT4...
...in mouse models of the disease. TARGET/MARKER/PATHWAY: Glycerol-3-phosphate acyltransferase mitochondrial (GPAT; GPAM); glycerol-3-phosphate acyltransferase-3 (GPAT3); GPAT4...
BioCentury | Dec 19, 2006
Clinical News

New triglyceride enzyme found

Researchers at Wyeth (WYE) reported in the Proceedings of the National Academy of Sciences the identification of human and mouse genes that encode for Acyl-CoA: glycerol-3-phosphate acyltransferase-3 (GPAT-3) , a microsomal enzyme shown to be key...
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