17:26 , Apr 22, 2019 |  BC Innovations  |  Distillery Therapeutics

GPX4 inhibitors for ovarian and renal clear cell carcinomas

DISEASE CATEGORY: Cancer INDICATION: Ovarian cancer; renal cancer Cell culture and mouse studies identified GPX4 inhibitors that could help treat ovarian clear cell carcinoma and clear cell renal cell carcinoma (ccRCC). Analysis of a database...
02:24 , Mar 29, 2019 |  BC Innovations  |  Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

New and emerging targets at AACR 2019 show cancer researchers are gaining granularity on how to manipulate the tumor microenvironment, a top priority goal for the field. The targets point to emerging strategies for modulating...
20:32 , Nov 6, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Cancer; solid tumors Cell culture and mouse studies suggest inhibiting GPX4 could help treat relapsing, drug-resistant cancers. In human breast, lung, melanoma and ovarian cancer cell lines, a GPX4 inhibitor tool compound induced higher...
23:32 , Nov 2, 2017 |  BC Extra  |  Preclinical News

Researchers suggest GPX4 inhibition to treat drug-resistant cancer

In a paper published in Nature , researchers at the University of California San Francisco and colleagues showed that persister cells from a range of cancers depend on glutathione peroxidase 4 (GPX4) for survival, suggesting...
01:21 , Jan 27, 2017 |  BC Innovations  |  Targets & Mechanisms

Death metal

The findings in two high profile papers on ferroptosis could be the nudge the fledgling field needs to gain the attention of drug developers. The process is the latest cell death pathway to offer up...
17:07 , Dec 18, 2014 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Glutathione peroxidase-4 (GPX4)

Cardiovascular INDICATION: Ischemia / reperfusion injuryMouse studies suggest inhibiting ferroptosis could help treat ischemia / reperfusion injury in the liver and kidney. The GPX4 enzyme decreases toxic phospholipid hydroperoxides associated with ferroptosis, an apoptosis- and...
08:00 , Feb 13, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Glutathione peroxidase 4 (GPX4) In vitro and mouse studies suggest inhibiting GPX4 could help treat cancer by inducing ferroptosis. Ferroptosis...