BioCentury | Dec 6, 2019
Targets & Mechanisms

Emerging immuno-oncology mechanisms at ASH 2019

...and T lymphocyte attenuator CTLA-4 (CTLA4; CD152) - Cytotoxic T-lymphocyte associated protein 4 GPX4 - Glutathione peroxidase...
...of MIT and Harvard Cardiff University Parker Institute for Cancer Immunotherapy Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) (CTLA4) (CD152) Glutathione peroxidase...
BioCentury | Jun 28, 2019
Clinical News

June 28 Clinical Quick Takes: Imfinzi extends survival in Phase III SCLC study; plus LSK, Pfizer, FibroGen, Aclaris and more

...measured by Pure Tone Audiometry, meeting a primary efficacy endpoint. The selenium-based small molecule, a GPX...
BioCentury | Jun 26, 2019
Clinical News

June 25 Clinical Quick Takes: Minerva meets in insomnia; plus Aldeyra, Genkyotex and more

...The PI3Kδ inhibitor is in Phase II testing for third-line follicular lymphoma. Targets: GPX - glutathione peroxidase...
BioCentury | Apr 22, 2019
Distillery Therapeutics

GPX4 inhibitors for ovarian and renal clear cell carcinomas

...steps could include testing the inhibitors in mouse models of ovarian clear cell carcinoma. TARGET/MARKER/PATHWAY: Glutathione peroxidase...
...Harvard, Cambridge, Mass.; Harvard University, Cambridge, Mass. email: stuart_schreiber@harvard.edu Sandi Wong Broad Institute of MIT and Harvard Harvard University Glutathione peroxidase...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...include enzymes controlling oxidation. The NADPH oxidase NOX4, which generates reactive oxygen species, and the glutathione peroxidase...
...domain containing 5 DHFR - Dihydrofolate reductase FOXC2 (MFH-1) - Forkhead box C2 GPX4 - Glutathione peroxidase...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...FAS) 3 ATP citrate lyase (ACLY) 2 Glutamine pathway Glutaminase (GLS) 3 Glutathione peroxidase (GPX) 3 Glutathione peroxidase...
BioCentury | Nov 30, 2017
Clinical News

Sound reports Phase Ib data for SPI-1005 in Meniere's disease

...recognition, tinnitus loudness and vertigo severity vs. placebo. The selenium-based small molecule mimic of glutathione peroxidase (GPX...
...target: Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NRF2) Description: Selenium-based small molecule mimic of glutathione peroxidase (GPX...
BioCentury | Nov 17, 2017
Company News

Monopar acquires cancer candidate from Gem, raises $9.7M

...Cancer company Monopar Therapeutics Inc. (Northbrook, Ill.) said it acquired candidates including GPX-150 from Gem Pharmaceuticals...
...and August. Investors in the private placements included Hendriks Holdings Co. and undisclosed family offices. GPX-150...
...treatment for metastatic and non-resectable soft tissue sarcoma (STS). In the 22-patient trial, Monopar said GPX-150...
BioCentury | Nov 6, 2017
Distillery Therapeutics

Cancer

...has the compound in Phase I/II and Phase III testing for other solid tumors. TARGET/MARKER/PATHWAY: Glutathione peroxidase...
...frank.mccormick@ucsf.edu CONTACT: Michael McManus, same affiliation as above email: michael.mcmanus@ucsf.edu Elizabeth S. Eaton Mekinist Tafinlar University of California San Francisco Glutathione peroxidase...
BioCentury | Nov 2, 2017
Preclinical News

Researchers suggest GPX4 inhibition to treat drug-resistant cancer

...San Francisco and colleagues showed that persister cells from a range of cancers depend on glutathione peroxidase...
...potential strategy to prevent tumor relapse. Elizabeth S. Eaton Mekinist Tafinlar Columbia University Japan Tobacco Inc. Novartis AG University of California San Francisco Glutathione peroxidase...
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