BioCentury | Feb 7, 2019
Preclinical News

Novo, MIT develop oral biologic delivery device

...adverse effects. The team also showed that manufacturing SOMA devices loaded with insulin, lysozyme or glucose-6-phosphate dehydrogenase (G6PD)...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...GPX1) 3 Glycolysis Solute carrier family 2 facilitated glucose transporter member 1 (SLC2A; GLUT1) 4 Glucose-6-phosphate dehydrogenase (G6PD)...
BioCentury | Apr 3, 2018
Distillery Therapeutics

Cancer

...and mouse studies suggest inhibiting the pentose phosphate pathway with PP2A inhibitor LB-100, inhibition of G6PD...
...from patients with B cell ALL and B cell lymphoma, LB-100 or a tool compound G6PD...
...alone. In a patient-derived xenograft (PDX) mouse model of B cell lymphoma, LB-100 plus the G6PD...
BioCentury | Aug 3, 2017
Tools & Techniques

The other side of the Rubicon

...Genomics Journal of Assisted Reproduction and Genetics Protein & Cell Indication Hypertrophic cardiomyopathy β thalassemia; glucose-6-phosphate dehydrogenase (G6PD)...
...Recessive; Recessive N/A Recessive Target gene Myosin binding protein C cardiac (MYBPC3) β globin (HBB); G6PD...
BioCentury | Apr 14, 2017
Clinical News

Personal Genome Service Genetic Health Risk (GHR) test regulatory update

...SERPINA1) deficiency, early-onset primary dystonia, Factor XI deficiency, Gaucher's disease Type I, glucose-6 phosphate dehydrogenase (G6PD...
BioCentury | Mar 10, 2017
Clinical News

China scientists edit genes with CRISPR in viable human embryos

...mutations in beta globin (HBB) and glucose-6-phosphate dehydrogenase (G6PD) . Those mutations are associated with β-thalassemia and G6PD...
...of which was successfully repaired with homology-directed recombination (HDR). In each of two embryos with G6PD...
BioCentury | Nov 5, 2015
Distillery Therapeutics

Therapeutics: Glucose-6-phosphate dehydrogenase (G6PD)

...Cancer INDICATION: Lung cancer Studies in patient samples, cell culture and mice suggest inhibiting G6PD glycosylation...
...treat lung cancer. Lung tissue from patients with lung cancer had higher levels of glycosylated G6PD...
...could include identifying inhibitors of G6PD glycosylation and testing in models of lung cancer. TARGET/MARKER/PATHWAY: Glucose-6-phosphate dehydrogenase (G6PD)...
BioCentury | Nov 21, 2013
Distillery Techniques

Technology: Disease models

...cause hemolytic anemia in patients with inherited glucose-6-phosphate dehydrogenase (G6PD) deficiency. In immunocompromised mice engrafted with human G6PD-deficient...
BioCentury | Aug 9, 2012
Distillery Therapeutics

Indication: Infectious disease

...status Publication and contact information Infectious disease Malaria Glucose-6-phosphate dehydrogenase (g6pd) In vitro studies identified Plasmodium falciparum g6pd...
...throughput screen of about 350,000 compounds, benzothiazinones were the most potent inhibitors of P. falciparum g6pd...
BioCentury | May 10, 2012
Distillery Therapeutics

Indication: Cancer

...study identified G6PD inhibitors that could be useful for treating solid tumors. Previous studies suggested G6PD...
...tumor growth. In vitro SAR experiments identified derivatives of dehydroepiandrosterone (DHEA), a weak inhibitor of G6PD...
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