BioCentury | Sep 4, 2019
Clinical News

Gene therapy data weigh on Ultragenyx shares

...in the study’s first cohort. The genetic disorder is characterized by a defective glucose-6-phosphatase catalytic subunit-related protein (G6PC; G6Pase...
...the first cohort had mild ALT elevations. Ultragenyx acquired the adeno-associated viral (AAV) vector delivering G6PC...
...Study of Inborn Errors of Metabolism (SSIEM) symposium in Rotterdam. Stephen Hansen, Associate Editor DTX401, DTX401 AAV G6Pase Ultragenyx...
BioCentury | May 8, 2019
Preclinical News

May 8 Preclinical Quick Takes: Moderna, WntRx, schizophrenia, heart attack

...new preclinical mRNA candidate to treat glycogen storage disease type Ia -- mRNA-3745, which encodes G6PC...
...death in some pigs. Targets: BCL9 - B cell CLL lymphoma 9; G6PC (G6Pase) - Glucose-6-phosphatase catalytic subunit-related protein...
...Writer Fudan University Harvard University King's College London Moderna Inc. University of Cambridge B cell CLL lymphoma 9 (BCL9) Beta-catenin (CTNNB1) Glucose-6-phosphatase catalytic subunit-related protein (G6PC) (G6Pase) Phospholipase...
BioCentury | Nov 30, 2017
Translation in Brief

Two faces of FOXO1

...box O1 (FOXO1). The transcription factor boosts glucose production by triggering expression of glucose-6-phosphatase catalytic subunit-related protein (G6PC; G6Pase...
...utilization and lipogenesis by blocking glucokinase (GCK; GK). While the mechanism by which FOXO1 regulates G6PC...
...director of the Columbia University Diabetes and Endocrinology Research Center. His group showed that, unlike G6PC...
BioCentury | Sep 22, 2017
Company News

Ultragenyx counters RegenxBio with bid for Dimension

...its next lead candidate DTX401 , an AAV vector that delivers glucose-6-phosphatase catalytic subunit-related protein ( G6PC ; G6Pase...
...Gene/cell therapy, Endocrine/Metabolic Elizabeth S. Eaton burosumab DTX301 DTX401 KRN23 Dimension Therapeutics Inc. RegenxBio Inc. Ultragenyx Pharmaceutical Inc. Fibroblast growth factor 23 (FGF23) Glucose-6-phosphatase catalytic subunit-related protein (G6PC) (G6Pase) Glucuronidase...
BioCentury | Sep 18, 2017
Company News

Ultragenyx counters RegenxBio with bid for Dimension

...its next lead candidate DTX401 , an AAV vector that delivers glucose-6-phosphatase catalytic subunit-related protein ( G6PC ; G6Pase...
...Ultragenyx slipped $2.24 to $52.99 on Monday. Elizabeth S. Eaton DTX301 DTX401 Dimension Therapeutics Inc. RegenxBio Inc. Ultragenyx Pharmaceutical Inc. Glucose-6-phosphatase catalytic subunit-related protein (G6PC) (G6Pase) Ornithine...
BioCentury | Sep 1, 2017
Company News

RegenxBio acquiring gene therapy play Dimension

...slated for early 2018 for DTX401, an AAV vector that delivers glucose-6-phosphatase catalytic subunit-related protein ( G6PC ; G6Pase...
...NASDAQ:RGNX), Rockville, Md. Business: Gene/Cell therapy, Endocrine/Metabolic, Hematology Chris Lieu DTX101 DTX201 DTX301 DTX401 Bayer AG Dimension Therapeutics Inc. RegenxBio Inc. Factor IX Glucose-6-phosphatase catalytic subunit-related protein (G6PC) (G6Pase) Ornithine...
BioCentury | Aug 25, 2017
Company News

RegenxBio acquiring gene therapy play Dimension

...slated for early 2018 for DTX401, an AAV vector that delivers glucose-6-phosphatase catalytic subunit-related protein ( G6PC ; G6Pase...
...$21.05, and Dimension jumped $1.95 (163%) to $3.15. Chris Lieu DTX101 DTX201 DTX301 DTX401 Bayer AG Dimension Therapeutics Inc. RegenxBio Inc. Factor IX Glucose-6-phosphatase catalytic subunit-related protein (G6PC) (G6Pase) Ornithine...
BioCentury | May 25, 2015
Emerging Company Profile

Dimension's intentions

...affects about 10,000 patients worldwide. DTX401 is an AAV vector delivering glucose-6-phosphatase catalytic subunit-related protein ( G6PC ; G6Pase...
BioCentury | Aug 10, 2009
Company News

GlyGenix Therapeutics, Philips deal

...of using Royal Philips' ultrasound-mediated DNA delivery technology with the biotech's glucose-6-phosphatase catalytic subunit-related protein ( G6PC , G6Pase...
BioCentury | Dec 18, 2008
Distillery Therapeutics

This week in therapeutics

...Licensing status Publication and contact information Metabolic disease Von Gierke's disease Glucose-6-phosphatase catalytic subunit (G6PC; G6Pase...
...caused by mutations in G6PC. In mice, liver-specific knockout of Src2 decreased hepatic levels of G6PC...
...fasting hypoglycemia-a phenotype similar to that of Von Gierke's disease. Adenoviral overexpression of Rora increased G6pc...
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