BioCentury | Oct 16, 2020
Finance

VectivBio prepping pivotal GI trial with $110M crossover round that could presage IPO

...advocates and communities. “It’s unlikely that we’ll expand into more primary care GI opportunities.”TARGETSGLP-2 - Glucagon-like...
BioCentury | Sep 30, 2020
Distillery Therapeutics

An FGF21, GLP-1 fusion protein for diabetes, obesity

...and HbA1c levels compared with FGF21 or GLP-1 monotherapy.TARGET/MARKER/PATHWAY: Fibroblast growth factor 21 (FGF21); glucagon-like peptide-1 (GLP-1); glucagon-like...
...Sci. Adv.; published online Aug. 26, 2020doi:10.1126/sciadv.aaz9890CONTACT: Ashutosh Chilkoti, Duke University, Durham, N.C.email: chilkoti@duke.edu Claire Quang Duke University Glucagon-like...
BioCentury | Sep 30, 2020
Distillery Therapeutics

Endogenous bile acid identified for obesity and diabetes

...for inflammatory bowel disease and non-infectious diarrhea.TARGET/MARKER/PATHWAY: G protein-coupled bile acid receptor 1 (GPBAR1; TGR5); glucagon-like...
BioCentury | Sep 30, 2020
Product Development

Partner Amgen becomes investor as Carmot pushes diabetes therapies ahead with $47M series C

...– Gastric inhibitory polypeptide receptorGLP-1R (GLP1R) – Glucagon-like...
...Martz Carmot Therapeutics Inc. Amgen Inc. KRAS proto-oncogene, GTPase (KRAS) (K-Ras) Glucagon-like...
BioCentury | Sep 25, 2020
Product Development

Novo makes obesity pick as amylin/GLP-1 combo promises gastric bypass-like efficacy

...strongly argue it is unethical not to treat obesity.Glucagon...
...big opportunities in obesity. The former is a glucagon (GCG)...
...and GLP-1 co-agonist. The latter is a glucagon/GLP-1/GIP...
BioCentury | Jul 28, 2020
Emerging Company Profile

Frazier, Marcadia founders reunite for rare endocrine diseases in MBX’s $34.6M A round

...molecules without increasing product size. One example of his work is a hybrid compound, dubbed glucagon/T3...
BioCentury | Jul 10, 2020
Finance

How buysiders are sizing up commercial launches during the pandemic

...Tumor necrosis factor receptor superfamily member 17 CGRP - Calcitonin gene-related peptide GLP-1 - Glucagon-like...
BioCentury | Jun 19, 2020
Product Development

Hua shows sustained benefit in diabetics with glucokinase activator

...testing for depression, anxiety and Fragile X syndrome. Targets GCK (GK) - Glucokinase GLP-1 - Glucagon-like...
BioCentury | Jun 11, 2020
Deals

With $725M Corvidia takeout, Novo gets clinical atherosclerosis asset

...as Rybelsus. Targets APOCII (APOC2) - Apolipoprotein C-II APOCIII (APOC3) - Apolipoprotein C-III GLP-1 - Glucagon-like...
BioCentury | May 14, 2020
Emerging Company Profile

Kriya emerges with $80.5M A round, three gene therapies for diabetes and obesity

...Transhuman Capital CEO: Shankar Ramaswamy Patents: Undisclosed Targets GCK (GK) - Glucokinase GLP-1R 9GLP1R) - Glucagon-like...
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