17:39 , Jul 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Diabetes Cell culture studies suggest inhibiting TGFBR1 could help treat GLIS3-mutant diabetes. Screening of a library of approved drugs, drug-like compounds and tool compounds in GLIS3-knockout human pancreatic progenitor β cells identified that the TGFBR1...
07:00 , Apr 7, 2016 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockoutsGLIS3-knockout mice transgenically expressing chicken LYZ in pancreatic β cells could be useful for screening therapies to treat Type I and Type II diabetes. In mice, systemic heterozygous knockout of GLIS3 and transgenic...
07:00 , Apr 7, 2016 |  BC Innovations  |  Translation in Brief

Knowing when to fold

A team from the Flanders Institute for Biotechnology (VIB) has linked two genes involved in the unfolded protein stress response to the fragility of pancreatic β cells involved in both Type I and Type II...
07:00 , Jun 4, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease ...