BioCentury | Jun 20, 2020
Product Development

Regeneron’s commercial future

...a Phase III trial in OA in 2018. Targets C5 - Complement 5 GFRA3 - Glial cell line-derived neurotrophic factor family receptor alpha...
BioCentury | Feb 27, 2014
Distillery Therapeutics

Indication: Neurology

...factor family receptor a1 (GFRA1) Studies in mice suggest a small molecule positive modulator of GFRA1...
...from reduced glial cell-derived neurotrophic factor (GDNF) levels or diabetes, topical application of a positive GFRA1...
BioCentury | Dec 13, 2010
Strategy

Unwinding Biovail's Deals

...10-25% royalties; no termination fee Jan-10 MedGenesis Therapeutix Inc. Glial cell-derived neurotrophic factor (GDNF) protein Glial cell line-derived neurotrophic factor family receptor (GFR) alpha 1 (GFRA1)...
BioCentury | Nov 8, 2010
Clinical News

Glial derived neurotrophic factor: Development discontinued

...Mississauga, Ontario Product: Glial derived neurotrophic factor (GDNF) ( BVF-014 ) Business: Neurology Molecular target: Glial cell line-derived neurotrophic factor family receptor (GFR) alpha 1 (GFRA1)...
BioCentury | Jan 28, 2010
Distillery Therapeutics

Indication: Cancer

...receptor a1 (GFRA1); ret proto-oncogene (RET) Studies in mice suggest that inhibiting signaling through the GDNF-GFRA1-RET...
...tissue compared with vehicle. Next steps include evaluating the effects of inhibiting signaling through the GDNF-GFRA1-RET...
BioCentury | Feb 14, 2005
Clinical News

Glial derived neurotrophic factor: Phase II halted

...Inc. (AMGN), Thousand Oaks, Calif. Product: Glial derived neurotrophic factor (GDNF) Business: Neurology Molecular target: Glial cell line-derived neurotrophic factor family receptor (GFR) alpha...
BioCentury | Jul 5, 2004
Clinical News

Glial derived neurotrophic factor: Phase II data

...Inc. (AMGN), Thousand Oaks, Calif. Product: Glial derived neurotrophic factor (GDNF) Business: Neurology Molecular target: Glial cell line-derived neurotrophic factor family receptor (GFR) alpha...
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