BioCentury | Sep 19, 2017
Distillery Therapeutics

Cancer

...dihydrobenzooxazocin analog yielded a compound that inhibited the activity of the hedgehog pathway signaling component GLI1...
...cells from a mouse model of medulloblastoma, the compound decreased proliferation and decreased expression of GLI1...
...testing for AML and hematologic malignancies and Phase I testing for myelodysplastic syndrome (MDS). TARGET/MARKER/PATHWAY: GLI family zinc finger 1 (GLI1)...
BioCentury | Jul 10, 2017
Distillery Therapeutics

Cancer

...INDICATION: Lung cancer Patient sample, cell culture and mouse studies suggest inhibiting GLI1 alone or in...
...normal lung tissues. In a human lung SCC cell line, knockdown of GLI1 or the GLI1...
...model of SCC of the lung, tumor-specific GLI1 knockdown decreased tumor growth compared with normal GLI1...
BioCentury | May 31, 2017
Distillery Therapeutics

Hematology

...INDICATION: Myeloproliferative disorder Patient sample and mouse studies suggest inhibiting GLI1 -expressing cells could help treat...
...In patients with higher grades of MPN, bone marrow samples had a higher percentage of GLI1-expressing...
...spleen weight compared with vehicle. Next steps include identifying therapeutic targets on GLI1-expressing cells. TARGET/MARKER/PATHWAY: GLI family zinc finger 1 (GLI1)...
BioCentury | Feb 2, 2017
Translation in Brief

Repairing repair

...of hedgehog signaling pathway components - including Indian hedgehog homolog (IHH) , smoothened (SMO) and GLI family zinc finger 1 (GLI1)...
...human tissue samples. In patients undergoing joint replacement, the group found levels of IHH and GLI1...
...rescue of diabetic skeletal stem cell niches.” Science Translational Medicine (2017) - Mary Romeo Mary Romeo Stanford University GLI family zinc finger 1 (GLI1) Indian...
BioCentury | Feb 1, 2017
Distillery Therapeutics

Musculoskeletal

...could help treat diabetes-associated bone fractures. In patients undergoing joint replacement, levels of IHH and GLI family zinc finger 1 (GLI1)...
...samples from a mouse model of diabetes with a femoral fracture, levels of IHH and GLI1...
...Stanford, Calif. email: chazchan@stanford.edu CONTACT: Michael T. Longaker, same affiliation as above email: longaker@stanford.edu Mary Romeo Stanford University GLI family zinc finger 1 (GLI1) Indian...
BioCentury | Dec 22, 2016
Targets & Mechanisms

Opportunity Knocks

...neurotrophic factor (BDNF) 13 Cancer; neurology CREB binding protein (CREBBP; CBP) 12 Cancer; neurology Glioma-associated oncogene homolog 1 zinc finger protein (GLI1...
BioCentury | Nov 30, 2016
Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest c-MET inhibitors could help treat pediatric glioblastomas expressing c-MET fusion oncogenes. In human pediatric glioblastoma cell lines, the c-MET inhibitor foretinib inhibited growth with a lower...
BioCentury | Oct 6, 2016
Distillery Therapeutics

Therapeutics: GLI family zinc finger 1 (GLI1)

...Cardiovascular disease INDICATION: Atherosclerosis Patient sample and mouse studies suggest inhibiting GLI1 could help treat atherosclerosis...
...disease (CKD). In patient samples of arterial atherosclerotic plaques and calcified tunica media, levels of GLI1...
...steps could include identifying and testing GLI1 inhibitors in the models of CKD-associated atherosclerosis. TARGET/MARKER/PATHWAY: GLI family zinc finger 1 (GLI1)...
BioCentury | Sep 15, 2016
Targets & Mechanisms

KOR-recting MS

...the maturation of the differentiated cells (see "Differential Effect," page 6). One of the targets, GLI1...
...Planck Institute for Experimental Medicine Mark Kotter GLI family zinc finger 1 (GLI1) Antagonist Nature (2015) Studies in mice suggest GLI1...
BioCentury | Aug 8, 2016
Clinical News

SUBA-Itraconazole: Interim Phase IIb data

...to next therapy, change in number of jaw cysts and palmar/plantar pits and glioma-associated oncogene homolog 1 zinc finger protein ( GLI1...
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