BioCentury | Aug 22, 2019
Distillery Therapeutics

Enhancing dopamine receptor and ghrelin receptor activity to prevent β amyloid damage

...DISEASE CATEGORY: Neurology INDICATION: Alzheimer's disease (AD) Jointly agonizing DRD1 and the 1α isoform of GHSR...
...hippocampal brain tissues from AD patients and an AD mouse model had higher levels of GHSR...
...the human and mouse samples, and in HEK cells the interaction induced dysfunction and blocked GHSR...
BioCentury | Dec 22, 2017
Clinical News

FDA approves Aeterna's Macrilen

...Inc. (TSX:AEZS; NASDAQ:AEZS), Charleston, S.C. Product: Macrilen macimorelin acetate (Macrimorelin-GHST, AEZS-130) Business: Diagnostic Meghan Sullivan Macrilen Aeterna Zentaris Inc. Ghrelin receptor (GHSR)...
BioCentury | Dec 21, 2017
Company News

Aeterna jumps on Macrilen approval

...Macrilen. Aeterna resubmitted the NDA in June. Macrilen is also under EMA review. Meghan Sullivan Macrilen Aeterna Zentaris Inc. Ghrelin receptor (GHSR)...
BioCentury | Dec 14, 2017
Translation in Brief

Ghrelin’s LEAP forward

...by selectively antagonizing GHSR -- the ghrelin receptor. Against a panel of GPCRs, LEAP2 selectively antagonized GHSR...
...GHSR and how it works. He added that his group saw counter-regulation of LEAP2 and GHSR...
...Is an endogenous antagonist of the ghrelin receptor.” Cell Metabolism (2017) Lauren Martz, Senior Writer MedImmune LLC NGM Biopharmaceuticals Inc. Ghrelin Ghrelin receptor (GHSR) Cachexia...
BioCentury | Dec 8, 2017
Clinical News

EMA reviewing Aeterna Zentaris' Macrilen to evaluate AGHD

...TSX:AEZS; NASDAQ:AEZS), Charleston, S.C. Product: Macrilen macimorelin acetate (Macrimorelin-GHST, AEZS-130) Business: Diagnostic Allison Johnson AEZS-130 macimorelin acetate Macrilen Macrimorelin-GHST Aeterna Zentaris Inc. Ghrelin receptor (GHSR)...
BioCentury | Aug 4, 2017
Clinical News

FDA accepts Aeterna's resubmitted NDA for GHD candidate Macrilen

...Charleston, S.C. Product: Macrilen macimorelin acetate ( Macrimorelin-GHST , AEZS-130) Business: Diagnostic Alicia Parker AEZS-130 macimorelin acetate Macrilen Macrimorelin-GHST Aeterna Zentaris Inc. Ghrelin receptor (GHSR)...
BioCentury | Jul 31, 2017
Distillery Techniques

Imaging

...TECHNOLOGY: PET A ghrelin -based PET imaging agent could help diagnose GHSR -expressing ovarian, prostate, testicular...
...peptide modified to contain isonipecotic acid, diaminopropionic acid, naphthoate groups and threonine substitutions that bound GHSR...
...PET agent in animal models of GHSR-expressing cancers. DESCRIPTION: Ghrelin-based PET imaging agent to diagnose ghrelin receptor (GHSR)-expressing...
BioCentury | May 26, 2017
Clinical News

CHMP recommends against Helsinn's Adlumiz

...Product: Adlumiz anamorelin ( ONO-7643 ) (formerly RC-1291) Business: Endocrine/Metabolic Julian Zhu Anamorelin ONO-7643 Helsinn Healthcare S.A. Ono Pharmaceutical Co. Ltd. Ghrelin receptor (GHSR) Adlumiz...
BioCentury | May 1, 2017
Clinical News

Aeterna scraps Zoptrex after endometrial cancer miss

...tolerance test, but missed another co-primary endpoint measuring positive agreement. Jaime De Leon AEZS-130 macimorelin acetate Macrilen Macrimorelin-GHST zoptarelin doxorubicin Zoptrex Aeterna Zentaris Inc. Ghrelin receptor (GHSR) Luteinizing...
BioCentury | Mar 16, 2017
Targets & Mechanisms

Bone appétit!

...via actions on at least six receptors in the brain: INSR , MC4R, LEPR , GHSR...
...and GLP-1 receptors (see “Bone-Deep Hormones”). MC4R, LEPR and GLP-1 receptors decrease food intake, while GHSR...
...hormone γ-MSH - γ melanocyte stimulating hormone FGF23 - Fibroblast growth factor 23 GHSR - Ghrelin receptor...
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