BioCentury | Apr 15, 2010
Distillery Therapeutics

Indication: Cancer

...transferase; geranylgeranyltransferase I (PGGT1B; GGTase I) A study in mice suggests that antagonizing both farnesyl transferase and GGTase I...
...In mice with an activating mutation in K-Ras, genetic inactivation of both farnesyl transferase and GGTase I...
...transferase inactivation alone. Next steps include the development of dual inhibitors of farnesyl transferase and GGTase I...
BioCentury | May 11, 2009
Clinical News

GGTI-2418: Phase I started

...Fla. Product: GGTI-2418 Business: Cancer Molecular target: Geranylgeranyltransferase I (GGTase I) Description: Synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I...
BioCentury | Mar 9, 2009
Clinical News

GGTI-2418: Phase I start

...Product: GGTI-2418 Business: Cancer Molecular target: Geranylgeranyltransferase I (GGTase I) Description: Synthetic peptidomimetic inhibitor of geranyl-geranyltransferase I (GGTase I...
BioCentury | Jul 17, 2006
Company News

Tigris Pharmaceuticals, H. Lee Moffitt Cancer Center, University of South Florida, Yale University deal

...of VEGF and PDGF action, and GGTI-2418 , a synthetic peptidomimetic inhibitor of geranyl-geranyltransferase ( GGTase I...
BioCentury | Mar 25, 2002
Product Development

GPC pipeline

GPC pipeline Internal programs Indication Status Bryostatin-1 Cancer Phase II MHC class II antibody Cancer Preclinical CDK inhibitors (Mitotix) Cancer Preclinical Bryologs Cancer Preclinical Angiogenesis inhibitors(Mitotix) Cancer Preclinical Outlicensing, co-development MHC class II antibody Autoimmune...
BioCentury | Feb 25, 2002
Tools & Techniques

Displacing Ras

...addition of a prenyl group instead of a farnesyl group to the carboxy terminus by geranylgeranyltransferase I...
BioCentury | Sep 17, 2001
Clinical News

Geranylgeranyl transferase type 1 regulatory update

GPC and Johns Hopkins University (Baltimore, Md.) received U.S. Patent No. 6,271,197 covering screening assays to identify inhibitors of fungal GGTase activity. GPC is the exclusive licensee of the patent. GPC also received U.S. Patent...
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