22:51 , Jan 27, 2017 |  BioCentury  |  Emerging Company Profile

Cardiac conversion

Cell therapies that aim to reverse disease progression in heart failure and myocardial infarction by restoring cardiomyocytes are beginning to report positive clinical data, but they require frequent administration via invasive procedures. Tenaya Therapeutics Inc....
07:00 , Jun 16, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Forkhead box A1 (FOXA1); FOXA2; FOXA3; GATA binding protein 4 (GATA4); HNF1 homeobox A (HNF1A); hepatocyte nuclear factor 4 α (HNF4A; TCF) FOXA3,

Hepatic disease INDICATION: Liver fibrosis Mouse studies suggest in vivo reprogramming of liver myofibroblasts into hepatocyte-like cells could help treat liver fibrosis. In a mouse model of the disease, in vivo transduction of myofibroblasts with six adeno-associated...
08:00 , Dec 17, 2015 |  BC Innovations  |  Tools & Techniques

Heartfelt conversion

A group of Chinese and American researchers have developed the first virus-free cellular reprogramming method that can turn skin cells into cardiac progenitors at an efficiency high enough for clinical use. The U.S. arm is...
08:00 , Dec 3, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Heart and neural crest derivatives expressed 2 (HAND2); myocyte enhancer factor 2C (Mef2c); bone morphogenetic protein 4 (BMP4)

Cardiovascular disease INDICATION: Myocardial infarction (MI) Studies in cells and mice suggest a protein-based method for reprogramming human dermal fibroblasts into cardiac progenitor cells could help regenerate heart tissue after MI. In vitro, incubation of human dermal...
07:00 , May 31, 2012 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms In vivo reprogramming of cardiac fibroblasts into cardiomyocytes In vivo conversion of cardiac fibroblasts into cardiomyocytes could help treat...
07:00 , May 31, 2012 |  BC Innovations  |  Tools & Techniques

Reprogramming heart failure

Two groups at the University of California, San Francisco and The University of Texas Southwestern Medical Center have separately shown that delivering transcription factors directly to the heart reprogrammed cardiac fibroblasts and improved heart function...
07:00 , May 3, 2012 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms In vivo reprogramming of cardiac fibroblasts into cardiomyocytes In vivo conversion of cardiac fibroblasts into cardiomyocytes could help treat...
07:00 , Aug 19, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Reprogramming cardiac fibroblasts to produce cardiomyocytes for cardiac regeneration In vitro and mouse studies suggest that the transcription factors...
07:00 , Apr 30, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Transplantation

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Transplantation ...