17:52 , Aug 29, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Sepsis Cell culture and mouse studies identified a GSDMD inhibitor that could help treat sepsis. In vitro , the previously identified necroptosis inhibitor necrosulfamide bound GSDMD with a K d of 32 μM. In...
18:40 , Aug 28, 2018 |  BC Extra  |  Preclinical News

Stealth start-up Quench among teams tying protein to inflammatory cell death

Atlas Venture-backed start-up Quench Bio has partnered with a Max Planck Institute for Infection Biology team to target an inflammatory cell death pathway implicated in inflammatory and autoimmune diseases. The company, which is funded by...
01:19 , Jan 4, 2018 |  BC Innovations  |  Distillery Therapeutics

Ophthalmic disease

INDICATION: Age-related macular degeneration (AMD) Patient sample, cell culture and mouse studies suggest inhibiting cGAS, CASP4, GSDMD, IFNB1, IFNAR1, IRF3 or STAT2 could help treat geographic atrophy. In tissue samples from patients, levels of cGAS,...
23:39 , Oct 27, 2017 |  BC Extra  |  Preclinical News

Cell study points to new antibiotic strategy

A study in Cell shows granzyme B (GrB; GZMB), an immune cell protease, kills diverse bacterial species by shutting down multiple conserved survival pathways. The authors suggest compounds that mimic the protease’s mechanism could treat...